胎膜早破宫内感染产妇脐血和羊水中miR-182、TNF-α、S100B预测早产儿脑损伤价值  

Values of the levels of micro-ribonucleic acid 182,tumor necrosis factor-α and S100 calcium binding protein B in umbilical cord blood and in amniotic fluid of pregnant women for predicting the brain injury of their preterm infants

作　　者：黄立新 张淑艳 孙志敏 陈晓 杨月 沈文娟 李春玲 HUANG Lixin;ZHANG Shuyan;SUN Zhimin;CHEN Xiao;YANG Yue;SHEN Wenjuan;LI Chunling(Cangzhou Maternal and Child Health Care Hospital,Cangzhou,Hebei Province,061001)

机构地区：[1]河北省沧州市妇幼保健院,061001

出　　处：《中国计划生育学杂志》2024年第4期943-947,共5页Chinese Journal of Family Planning

基　　金：河北省卫建委医学科学研究课题计划(20241789)。

摘　　要：目的:探究胎膜早破宫内感染产妇脐血和羊水中微小核糖核酸182(miR-182)、肿瘤坏死因子-α(TNF-α)及S100钙结合蛋白B(S100B)预测早产儿脑损伤的临床价值。方法:选取2021年6月-2023年6月在本院分娩的104例胎膜早破宫内感染产妇临床资料,分娩的早产儿胎龄均<34周,行头部影像学检查,根据是否发生脑损伤将产妇分为脑损伤组(n=36)与非脑脑损伤组(n=68)。检测并比较两组脐血和羊水中miR-182、TNF-α、S100B蛋白水平,采用受试者工作特征(ROC)曲线评价胎膜早破宫内感染产妇脐血和羊水miR-182、TNF-α及S100B蛋白对早产儿脑损伤的预测价值。结果:脑损伤组脐血miR-182、TNF-α、S100B蛋白水平均高于非脑损伤组,羊水miR-182、TNF-α均高于非脑损伤组(均P<0.05),羊水中S100B蛋白水平两组无差异(P>0.05)。ROC曲线分析,脐血miR-182、TNF-α、S100B蛋白预测早产儿脑损伤的曲线下面积(AUC)分别为0.816、0.748、0.697,灵敏度分别为72.2%、66.7%、55.6%,特异度分别为83.8%、77.9%、88.2%;羊水miR-182、TNF-α、S100B蛋白预测早产儿脑损伤的AUC分别为0.713、0.689、0.594,灵敏度分别为63.9%、55.6%、30.6%,特异度分别为86.8%、85.3%、86.8%。结论:胎膜早破宫内感染产妇脐血和羊水中miR-182、TNF-α、S100B蛋白预测其早产儿脑损伤均有一定价值。Objective:To evaluate the clinical value of the levels of micro-ribonucleic acid 182(miR-182),tumor necrosis factor a(TNF-α)and S100 calcium binding proteinB(S100B)in umbilical cord blood and in amniotic fluid of pregnant women for predicting the brain injury of their preterm infants.Methods:The clinical data of 104 pregnant women with premature rupture of membranes and intrauterine infection from June 2021 to June 2023 were selected in this study.The gestational age at delivered of the preterm infants were less than 34 gestational weeks.The head imaging examination was performed for the infants of 104 women.Based on the infants brain injury occurrence or not,these women were divided into group A(36 women with the brain injury of their infants)and group B(68 women without the brain injury of their infants).The levels of miR-182,TNF-α and S100B proteins in maternal umbilical cord blood and in amniotic fluid of the women were detected and were compared between two groups.Receiver operating characteristic(ROC)curve was used to evaluate the values of the levels of miR-182,TNF-α and S100B proteins in maternal umbilical cord blood and in amniotic fluid of the women with premature rupture of membranes and intrauterine infection for predicting the brain injury of their infants.Results:The levels of the miR-182,TNF-α and S100B protein in cord blood of the women in group A were significantly higher than those of the women in group B,and the levels of the miR-182 and TNF-α in amniotic fluid of the women in group A were also significantly higher than those of the women in group B(all P<0.05).There was no significant difference in the S100B protein level in amniotic fluid of the women between the two groups(P>0.05).ROC curve analysis showed that the area under the curve(AUC)of the miR-182 level,the TNF-α level or the S100B protein level in cord blood of the women for predicting the brain injury of their preterm infants was 0.816,0.748 or 0.697,respectively.The sensitivity of which was 72.2%,66.7% or 55.6%,and the specif

关 键 词：胎膜早破 宫内感染 脐血 羊水 微小核糖核酸182 肿瘤坏死因子-α S100B蛋白 早产儿脑损伤 预测 

分 类 号：R714.433[医药卫生—妇产科学] R722.6[医药卫生—临床医学]