肠道菌群在儿童支气管哮喘发病机制中的研究进展  

Research progress on intestinal flora in the pathogenesis of children with bronchial asthma

作　　者：李楠[1] 王晓红[2] 马兰 LI Nan;WANG Xiaohong;MA Lan(The First Clinical Medicine School,Shanxi Medical University,Taiyuan 030001,Shanxi,China;Department of Pediatrics,First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China)

机构地区：[1]山西医科大学第一临床医学院,山西省太原市030001 [2]山西医科大学第一医院儿科,山西省太原市030001

出　　处：《广西医学》2024年第1期26-31,共6页Guangxi Medical Journal

摘　　要：支气管哮喘(以下简称哮喘)是一种在全球范围内发病率较高的慢性呼吸道疾病,近年来儿童哮喘发病率呈明显上升趋势。哮喘的发病机制极为复杂,目前未完全明确。研究表明,哮喘人群与健康人群的肠道菌群组成结构存在显著差异,肠道菌群可能通过调节T淋巴细胞亚群、树突状细胞、气道上皮细胞、黏膜免疫、相关信号通路等方式参与哮喘的发生和发展,而其代谢产物如短链脂肪酸、脂多糖、色氨酸、次级胆汁酸等也可能在哮喘发病中起着保护或促进的双重调控作用。本文就肠道菌群及其代谢产物在儿童哮喘发病机制中的研究进展进行综述。Bronchial asthma(hereinafter referred to as asthma)is a chronic respiratory disease with a high incidence rate worldwide.In recent years,the incidence rate of asthma in children has increased significantly.The pathogenesis of asthma is extremely complex,and it is not entirely clear.Studies have revealed that there is a significant difference in the composition structure of intestinal flora between asthma and healthy population,and intestinal flora may be involved in the occurrence and development of asthma through regulating T lymphocyte subsets,dendritic cells,airway epithelial cells,mucosal immune,related signaling pathways,and other approaches,whereas its metabolites such as short chain fatty acids,lipopolysaccharide,tryptophan,secondary bile acids may exert dual regulation effects of protection or promotion in the onset of asthma.In this review,research progress on intestinal flora and its metabolites in the pathogenesis of asthma in children is summarized.

关 键 词：支气管哮喘 肠道菌群 代谢产物 发病机制 儿童 综述 

分 类 号：R562.25[医药卫生—呼吸系统]