框架核酸在生物医学中的应用及其在核医学影像引导下的生物特性研究进展  

Advances in Research on Application of Framework Nucleic Acids in Biomedicine and Their Biological Characteristics Guided by Nuclear Medicine Imaging

作　　者：王昊 龙星如[1,2] 江大卫 兰晓莉 WANG Hao;LONG Xingru;JIANG Dawei;LAN Xiaoli(Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Hubei Key Laboratory of Molecular Imaging/Key Laboratory of Biological Targeted Therapy,the Ministry of Education,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科,湖北武汉430022 [2]分子影像湖北省重点实验室生物靶向治疗教育部重点实验室,湖北武汉430022

出　　处：《药学进展》2024年第3期178-185,共8页Progress in Pharmaceutical Sciences

摘　　要：框架核酸是一类具有独特物理、化学和生物特性的纳米组装寡核苷酸。根据沃森-克里克碱基配对规则,可以利用DNA配对杂交制备出各种形状和大小的DNA框架,这些框架具有高度可重复性和稳定性。通过将寡核苷酸编程组装成框架核酸,可以为研究纳米材料与生物体之间的相互作用提供高度可控的模型。概述了框架核酸在生物医学中的最新研究进展,旨在为DNA纳米技术的深入探索与应用提供参考。Framework nucleic acids(FNAs)are a class of nano-assembled oligonucleotides with unique physical,chemical and biological properties.According to the Watson-Crick base pairing rule,DNA frameworks of various shapes and sizes can be prepared by DNA pairing hybridization.These frameworks demonstrate high degree of reproducibility and stability.The programmable assembly of oligonucleotides into FNAs provides a highly controllable model for studying interactions between nanomaterials and living organisms.The latest research progress of FNAs in biomedicine was summarized in this article,aiming to provide reference for the further exploration and application of DNA nanotechnology.

关 键 词：框架核酸 纳米结构 核医学 生物医学应用 

分 类 号：R445.5[医药卫生—影像医学与核医学]