生物样本中游离脂肪酸和胆汁酸分析方法研究进展  

Research Progress in Analytical Methods for Free Fatty Acids and Bile Acids in Biological Samples

作　　者：李照乾 孙嘉睿 许风国[1] 张培[1] LI Zhaoqian;SUN Jiarui;XU Fengguo;ZHANG Pei(Ministry of Education Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学药物质量与安全预警教育部重点实验室,江苏南京210009

出　　处：《药学进展》2024年第3期229-236,共8页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(No.82073812,No.82104117,No.82173947,No.82273896);江苏省自然科学基金项目(No.BK20210427)。

摘　　要：游离脂肪酸和胆汁酸是两类均含有羧酸基团的内源性小分子代谢物,其结构多样、种类丰富,在调节机体新陈代谢、维持基本生命活动的过程中发挥着重要生理作用。研究表明,游离脂肪酸和胆汁酸的代谢紊乱与非酒精性脂肪肝、炎症性肠病、心脑血管疾病、糖尿病等疾病的发生发展密切相关,实现其高灵敏、宽覆盖定量分析对相关疾病早期诊断、机制研究、药物靶标发现等至关重要。总结了游离脂肪酸与胆汁酸的结构特点和分类,并对其分析方法研究进展进行了综述。Free fatty acids and bile acids are two types of endogenous small molecule metabolites with carboxylic acid groups.They have diverse structures and abundant varieties,and play important physiological roles in regulating the body's metabolism and maintaining basic life activities.Studies have shown that metabolic disorders of free fatty acids and bile acids are closely related to the occurrence and development of non-alcoholic fatty liver disease,inflammatory bowel disease,cardiovascular and cerebrovascular diseases,diabetes and other diseases.The realization of high-sensitivity and broad-coverage quantitative analysis is crucial for early diagnosis,mechanism research,and drug target discovery in related diseases.This article summarizes the structural characteristics and classification of free fatty acids and bile acids,and reviews the research progress in their analytical methods.

关 键 词：游离脂肪酸 胆汁酸 生物分析 代谢调控 

分 类 号：O657[理学—分析化学]