茉莉花重金属及有害元素的道地性研究及风险评估  

Study on geo-authenticity and risk assessment of heavy metal and harmful elements in Jasmine

作　　者：黄健军[1,2] 方刚 伍国怡[3] 邓刚 梁少东[3] 刘艳云 HUANG Jian-jun;FANG Gang;WU Guo-yi;DENG Gang;LIANG Shao-dong;LIU Yan-yun(Guangxi University of Chinese Medicine,Nanning530001,China;Guangxi Minzu University,Nanning530000,China;Beihai Institute for Food and Drug Control,Nanning530008,China)

机构地区：[1]广西中医药大学,南宁530001 [2]广西民族大学,北海536000 [3]北海市食品药品检验所,南宁530008

出　　处：《药物分析杂志》2024年第3期482-492,共11页Chinese Journal of Pharmaceutical Analysis

基　　金：2022年广西中医药大学面上项目(2022MS026);广西中医药多学科交叉创新资助(GZKJ2304);桂派中医药传承创新团队--壮医毒病临床医学研究与应用创新团队(桂中医大党[2022]23号);广西壮族自治区卫生健康委员会壮医应用基础研究重点实验室项目(广西中医药大学)(桂卫科教发[2020]17号);广西医学高层次骨干人才培养‘139’计划资助项目(桂卫科教发[2020]15号)。

摘　　要：目的:研究茉莉花重金属元素与道地性的相关性,并进行风险评估。方法:采用ICP-MS测定不同产区43批茉莉花重金属及有害元素含量的差异,进行聚类分析,研究茉莉花中各元素含量与道地性的相关性及水煎后各元素的溶出率,筛选可能影响重金属及有害元素含量的标志性元素,并进行风险评估。结果:不同产区43批茉莉花共聚为2类,不同产区茉莉花粉末和干膏中各重金属及有害元素含量大小均为Cu、Cd、Pb、As、Hg,粉末和干膏中Cu元素含量均大于其他元素;煎煮后各重金属及有害元素的溶出率大小为As、Pb、Hg、Cu、Cd、Pb、Cd与As是可能影响茉莉花重金属及有害元素含量的标志性元素;风险评估显示广西横州市横州镇(批号20200810)与福建省泉州市(批号20230705)MOEPb<1,存在一定暴露风险,其余产区危害指数和暴露限值均符合限值标准。结论:本文为种植区选择、人工育种、制定重金属及有害限量标准等方面提供科学依据。Objective:To study the correlation between heavy metal and harmful elements of Jasmine and the geo-authenticity,and to evaluate the risk.Methods:The content difference of heavy metal elements in 43 batches of Jasmine from different production areas was determined by ICP-MS,and cluster analysis was carried out to study the correlation between the content of each element in Jasmine and the geo-authenticity.The dissolution rate of each element after decocting in water was determined,the symbolic elements that might affect the contents of heavy metal and harmful elements was screened,and risk assessment was performed.Results:The copolymerization of 43 batches of jasmine from different producing areas was divided into 2 types.The contents of heavy metals in powder and dry paste of Jasmine from different producing areas declined in the order of Cu,Cd,Pb,As and Hg,and the content of Cu in powder and dry paste was higher than other elements.The dissolution rates of heavy metal and harmful elements declined in the order of As,Pb,Hg,Cu and Cd,and Pb,Cd and As were the representative elements that might affect the content of heavy metal and harmful elements in Jasmine.Risk assessment showed that MOE_(Pb)<1 existed in samples from Hengzhou Town,Hengzhou City,Guangxi Province(batch number:20200810)and Quanzhou City,Fujian Province(batch number:20230705),and the hazard index and exposure limit values in other producing areas were in line with the limit standards.Conclusion:This paper provides scientific basis for selection of planting area,artificial breeding and formulation of heavy metal and harmful limit standard.

关 键 词：茉莉花 道地性 重金属 有害元素 风险评估 

分 类 号：R917[医药卫生—药物分析学]