紫堇属植物苄基异喹啉类成分研究进展  

Research progress on benzylisoquinoline components from genus Corydalis

作　　者：邓超凡 江志波 马晓莉 南泽东 DENG Chao-fan;JIANG Zhi-bo;MA Xiao-li;NAN Ze-dong(Key Laboratory of State Ethnic Affairs Commission for Chemical Engineering and Technology,School of Chemistry and Chemical Engineering,North Minzu University;Innovative Team for Transforming Waste Cooking Oil into Clean Energy and High Value-added Chemicals,Yinchuan 750021,China)

机构地区：[1]北方民族大学化学与化学工程学院化工技术基础国家民委重点实验室 [2]宁夏餐厨废油转化清洁能源与高附加值化学品创新团队,银川750021

出　　处：《天然产物研究与开发》2024年第4期694-716,共23页Natural Product Research and Development

基　　金：宁夏自然科学基金一般项目(2022AAC03292);北方民族大学科研启动项目(2021KYQD35);宁夏重点研发计划引才专项(2021BEB04019);宁夏自然科学基金优秀青年项目(2022AAC05041)。

摘　　要：全球紫堇属Corydalis约400余种,广泛分布于北温带和非洲南部地区。在我国,该属多种物种作为民间用药具有上千年历史。紫堇属植物富含异喹啉生物碱,对该类成分通常以回流、超声加热、湿法超微粉碎法和酶解辅助技术等方法提取,并使用溶剂分离法、硅胶柱色谱法、反向填料柱色谱法、HPLC法、离子交换树脂法、高效逆流色谱法和活性引导技术等方法进行分离纯化法。紫堇属生物碱有效部位或单体成分都具有较强药理活性,现代药理学表明,该属所含生物碱类成分对心脑血管、抗肿瘤、镇痛、消炎、保肝和抗血小板凝集等均具有显著的药理作用。本文对已报道的紫堇属植物生物碱类成分的结构类型、特征、药理作用以及提取分离方法研究进行综述,为植物药用化学成分富集和安全用药提供借鉴。There are more than 400 species in the genus Corydalis,which widely distributed in the North temperate zone and southern Africa.In China,some of species of this genus have been used as folk medicine for thousands of years.Corydalis plants are rich in isoquinoline alkaloids,which were usually extracted by reflux,ultrasonic heating,wet ultrafine crushing and enzymolysis assisted technology,and separated and purified by solvent separation,silica gel column chromatography,ODS column chromatography,HPLC,ion exchange resin,HSCCC method and activity constituents guiding methods.Modern pharmacology assays have demonstrated that the alkaloids effective fractions or individual components of Corydalis possessed various pharmacological activities,such as cardiovascular and cerebrovascular effects,anti-tumor,analgesic,anti-inflammatory,liver protection,anti-platelet agglutination,etc.This paper presents an overview focusing on the structural types and characteristics the of benzylisoquinoline alkaloids,pharmacological effects and extraction methods of reported Corydalis genus,which can provide a reference for the further study on the enrichment of active components and safe utilization of genus Corydalis.

关 键 词：紫堇属 苄基异喹啉 生物碱 药理作用 提取方法 

分 类 号：R284[医药卫生—中药学] R285.5[医药卫生—中医学]