呋塞米与多巴胺低剂量给药调节心衰并肾功能不全患者的观察  

Observation of Low-dose Administration of Furosemide and Dopamine in Regulating Patients with Heart Failure and Renal Insufficiency

作　　者：刘赛磊 焦鹏[1] LIU Sailei;JIAO Peng(Cardiology Department,Shangqiu First People's Hospital,Shangqiu Henan 476000,China)

机构地区：[1]商丘市第一人民医院心内科,河南商丘476000

出　　处：《临床研究》2024年第5期66-68,共3页Clinical Research

摘　　要：目的 分析心力衰竭(CHF)合并肾功能不全患者接受呋塞米+低剂量多巴胺联合治疗的效果。方法 选取2022年10月至2023年10月期间商丘市第一人民医院收治的CHF合并肾功能不全的98例患者纳入研究病例,并以奇偶分组法为依据分为呋塞米治疗的参照组(n=49)、以参照组为基础联合低剂量多巴胺治疗的研究组(n=49),针对两组心肾功能、生活质量评分、不良反应展开比较。结果 治疗后,两组左心室射血分数(LVEF)、6 min步行距离(6MWT)指标均升高,脑钠肽(BNP)指标均降低,且研究组LVEF、6MWT指标高于参照组,BNP指标低于参照组,差异有统计学意义(P <0.01)。治疗后,两组血肌酐(Scr)、血尿素氮(BUN)、血尿酸(UA)指标均降低,且研究组低于参照组,差异有统计学意义(P <0.05)。治疗后,两组CQQC评分均上升,且研究组高于参照组,差异有统计学意义(P <0.05)。研究组不良反应发生率(6.12%)低于参照组(20.41%),差异有统计学意义(P <0.05)。结论 对CHF合并肾功能不全患者实施呋塞米+低剂量多巴胺治疗,可改善患者心肾功能,提高其生活质量,且显示出良好安全性。Objective To analyze the effect of combined treatment with furosemide and low-dose dopamine in patients with heart failure(CHF) and renal insufficiency.Methods A total of 98 patients with CHF complicated with renal insufficiency admitted to the First People's Hospital of Shangqiu City between October 2022 and October 2023 were selected as study cases,and were divided into a control group treated with furosemide(n=49) and a study group(n=49) treated with low-dose dopamine based on the control group using odd even grouping method.A comparison was made between the two groups in terms of heart and kidney function,quality of life score,and adverse reactions.Results After treatment,both groups showed an increase in left ventricular ejection fraction(LVEF) and 6-minute walking distance(6MWT),while a decrease in brain natriuretic peptide(BNP),the LVEF and 6MWT indicators in the study group were higher than those in the control group,while the BNP indicators was lower than those in the control group,and the difference was statistically significant(P < 0.01);After treatment,the indicators of blood creatinine(Scr),blood urea nitrogen(BUN),and blood uric acid(UA) in both groups decreased,and the indicators in the study group were lower than those in the control group,with statistical significance(P < 0.01);After treatment,the CQQC scores of both groups increased,and the study group was higher than the control group,with a statistically significant difference(P < 0.05).The incidence of adverse reactions in the study group(6.12%) was lower than that in the control group(20.14%)(P < 0.05).Conclusion The combination of furosemide and low-dose dopamine treatment for patients with CHF and renal insufficiency can effectively improve their cardiovascular and renal function,exert the effect of improving quality of life,and demonstrate good safety.

关 键 词：呋塞米 多巴胺 低剂量给药 心衰合并肾功能不全 心肾功能 生活质量 

分 类 号：R692[医药卫生—泌尿科学]