沙利度胺与二丁酰环磷腺苷钙治疗中重度寻常型银屑病临床比较  

Comparison Study of Thalidomide Versus Calcium Dibutyryladenosine Cyclophosphate in the Treatment of Moderate to Severe Psoriasis Vulgaris

作　　者：赵婧 顾丽群 刘海琴[2] ZHAO Jing;GU Liqun;LIU Haiqin(The Third Affiliated Hospital of Nantong University·Nantong Third People's Hospital,Nantong,Jiangsu,China 226001;Nantong Center for Disease Control and Prevention,Nantong,Jiangsu,China 226001)

机构地区：[1]南通大学附属南通第三医院·江苏省南通市第三人民医院,江苏南通226001 [2]江苏省南通市疾病预防控制中心,江苏南通226001

出　　处：《中国药业》2024年第8期102-105,共4页China Pharmaceuticals

基　　金：江苏省医院协会医院管理创新研究课题[JSYGY-3-2020-74]。

摘　　要：目的对比沙利度胺(THD)与二丁酰环磷腺苷钙(CDC)治疗中重度寻常型银屑病的临床疗效。方法选取南通大学附属南通第三医院2020年3月至2022年7月收治的中重度寻常型银屑病患者120例,按随机数字表法分为THD组和CDC组,各60例。两组患者皮疹处均外用尿素乳膏,THD组患者口服沙利度胺片,CDC组患者予注射用二丁酰环磷腺苷钙静脉滴注。两组患者均连续治疗5个月。结果THD组总有效率为98.33%,显著高于CDC组的86.67%(P<0.05)。THD组患者治疗后的受累体表面积及皮损面积和严重指数均显著低于CDC组,总胆固醇、甘油三酯、尿酸水平均显著低于CDC组,血清碱性成纤维细胞生长因子、血管内皮生长因子、肿瘤坏死因子-α、白细胞介素6、白细胞介素17水平均显著低于CDC组(P<0.05)。THD组不良反应发生率为3.33%,显著低于CDC组的20.00%(P<0.05),THD组患者治疗3,6个月内的再次住院率均显著低于CDC组(P<0.05)。结论与CDC比较,THD治疗中重度寻常型银屑病,可进一步改善血清学指标,且减轻皮损处炎性反应的效果更优。Objective To compare the clinical efficacy of thalidomide(THD)versus calcium dibutyryladenosine cyclophosphate(CDC)in the treatment of moderate to severe psoriasis vulgaris.Methods A total of 120 patients with moderate to severe divided into the THD group and the CDC group by the random number table method,with 60 cases in each group.The patients in the two groups were given topical urea cream at the rash site,on this basis,the patients in the THD group were given Thalidomide Tablets orally,while the patients in the CDC group were given intravenous drip of Calcium Dibutyryladenosine Cyclophosphate for Injection.Both groups were treated continuously for five months.Results The total effective rate in the THD group was 98.33%,which was significantly higher than 86.67%in the CDC group(P<0.05).After treatment,the body surface area(BSA),the psoriasis area and severity index(PASI)in the THD group were significantly lower than those in the CDC group;the total cholesterol(TC),triglyceride(TG)and uric acid(UA)levels were significantly lower than those in the CDC group;the serum basic fibroblast growth factor(bFGF),vascular endothelial growth factor(VEGF),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-17(IL-17)levels were significantly lower than those in the CDC group(P<0.05).The incidence of adverse reactions in the THD group was 3.33%,which was significantly lower than 20.00%in the CDC group(P<0.05).The readmission rates in the THD group within three and six months of treatment were significantly lower than those in the CDC group(P<0.05).Conclusion Compared with CDC,THD in the treatment of moderate to severe psoriasis vulgaris is more effective in improving serological indexes and relieving inflammatory reactions at skin lesions.

关 键 词：沙利度胺 二丁酰环磷腺苷钙 中重度寻常型银屑病 血清学指标 炎性因子 临床疗效 

分 类 号：R97[医药卫生—药品] R758.63[医药卫生—药学]