GRED对慢性阻塞性肺疾病患者血清IL-10 TGF-β_(1) sPD-1和sPD-L1表达水平及临床表现的影响  

Effect of Reflux Disease on the Expression Levels and Clinical Manifestations of Serum IL-10 TGF-β_(1) sPD-1 and sPD-L1 in Patients with Chronic Obstructive Pulmonary Disease

作　　者：许腾[1] 郝立君[1] 刘红春[1] 崔彦杰[1] XU Teng;HAO Lijun;LIU Hongchun(Xinjiang Uygur Autonomous Region People's Hospital,Xinjiang Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院临床检验中心,新疆乌鲁木齐830001

出　　处：《河北医学》2024年第4期575-579,共5页Hebei Medicine

基　　金：新疆维吾尔自治区自然科学基金资助项目(编号:2021D01C152)。

摘　　要：目的:分析胃食管反流病(GRED)对慢性阻塞性肺疾病(COPD)患者血清白细胞介素-10(IL-10)、转化生长因子-β_(1)(TGF-β_(1))、可溶性程序性死亡受体-1(sPD-1)和sPD-1配体(sPD-L1)表达水平及临床表现的影响。方法:选取我院2022年1月至2023年9月收治的104例COPD患者,按照患者是否合并反流性疾病,将其分别纳入合并组、未合并组。对比两组肺功能、IL-10、TGF-β_(1)、sPD-L1和sPD-1表达水平及临床表现差异。结果:104例COPD患者中,32例合并GERD,占30.77%。合并组IL-10低于未合并组,其TGF-β_(1)、sPD-1、sPD-L1均高于未合并组,差异有统计学意义(P<0.05)。合并组FEV1、FEV1/FVC、FEV1%均低于未合并组,差异有统计学意义(P<0.05)。合并组CASA-Q问卷咳嗽症状、咳嗽影响、咳痰症状、咳痰影响评分,以及mMRC评分和SGRQ问卷各项目评分、总分均高于未合并组,差异有统计学意义(P<0.05)。结论:近1/3的COPD患者合并GERD,且GERD与患者更为强烈的炎症反应和sPD-1、sPD-L1高表达有关,并伴有更差的肺功能和更严重的临床表现。Objective:To analyze the influence of gastroesophageal reflux disease(GRED)on the ex-pression levels and clinical manifestations of serum interleukin-10(IL-10),transforming growth factor-β_(1)(TGF-β_(1)),soluble programmed death receptor-1(sPD-1)and sPD-1 ligand(sPD-L1)in patients with chronic obstructive pulmonary disease(COPD).Methods:A total of 104 COPD patients admitted to our hos-pital from January 2022 to September 2023 were divided into combined group and non-combined group ac-cording to whether the patients were complicated with reflux disease.The lung function,IL-10,TGF-β_(1),sPD-L1 and sPD-1 expression levels and clinical manifestations were compared between the two groups.Re-sults:Among 104 COPD patients,32 cases were complicated with GERD,accounting for 30.77%.IL-10 in the combined group was lower than that in the non-combined group,and its TGF-β_(1),sPD-1 and sPD-L1 were higher than those in the non-combined group,with statistical significance(P<0.05).FEV1,FEV1/FVC and FEV1%in the combined group were lower than those in the non-combined group,and the difference was statistically significant(P<0.05).The combined group had higher cough symptoms,cough effects,ex-pectoration symptoms,expectoration effects scores,mMRC scores,SGRQ scores and total scores than the non-combined group,and the difference was statistically significant(P<0.05).Conclusion:Nearly one third of COPD patients are complicated with GERD,and GERD is related to the stronger inflammatory reaction and the high expression of sPD-1 and sPD-L1,accompanied by worse lung function and more serious clinical mani-festations.

关 键 词：慢性阻塞性肺疾病 反流性疾病 可溶性程序性死亡受体 

分 类 号：R563.9[医药卫生—呼吸系统]