血清白介素-6降钙素原及C反应蛋白水平与新生儿败血症预后的关系  

Relationship between Serum IL-6 PCT and CRP Levels and Prognosis of Neonatal Sepsis

作　　者：许爱华 顾涛[1] 李云[1] 方飞[1] 王静 XU Aihua;GU Tao;LI Yun(The First People's Hospital of Chuzhou City,Anhui Chuzhou 239000,China)

机构地区：[1]安徽省滁州市第一人民医院新生儿科,安徽滁州239000

出　　处：《河北医学》2024年第4期609-613,共5页Hebei Medicine

基　　金：2021年度安徽省卫生健康委科研项目(编号:AHWJ2021b005)。

摘　　要：目的:分析白介素-6(Interleukin,IL-6)、降钙素原(Procalcitonim,PCT)及C反应蛋白(C-Reactive protein,CRP)与新生儿败血症预后的关系。方法:选取2020年8月至2023年3月我院收治的新生儿败血症患儿86例为研究对象。分析治愈/好转组与死亡组的一般资料,对比两组患儿不同时期血清IL-6、PCT、CRP水平,分析影响新生儿败血症患儿预后的相关因素。结果:86例新生儿败血症患儿中,治愈/好转组有77例患儿,死亡组有9例患儿(死亡组患儿在12h内死亡4例,2d死亡2例,3d死亡2例,5d死亡1例)。在发病12h、12~36h内以及7d内,死亡组IL-6>7pg/mL比例、PCT>0.5ng/mL比例、CRP>10mg/mL比例均高于治愈/好转组,差异有统计学意义(P<0.05);两组性别、是否胎膜早破、是否为早产儿、有无黄疸、以及分娩方式等指标比较,差异无统计学意义(P>0.05);两组胎龄、出生时体重、0~6岁小儿神经心理发育检查表比较,差异有统计学意义(P<0.05);经过多因素Logistic回归分析显示,0~6岁小儿神经心理发育检查表、IL-6、PCT、CRP是影响新生儿败血症预后的独立危险因素(P<0.001)。结论:血清IL-6、PCT、CRP水平是影响新生儿败血症患儿预后的相关因素,监测血清IL-6、PCT、CRP水平,或可为临床调整新生儿败血症治疗策略提供可靠参考资料。Objective:To investigate the relationship between serum interleukin-6(IL-6),procalcito-nin(PCT),and C-reactive protein(CRP)levels and the prognosis of neonatal sepsis.Methods:A total of 86 neonates with sepsis admitted to our hospital from August 2020 to March 2023 were enrolled as the study subjects.The general data of the cured/improved group and the death group were analyzed.The serum IL-6,PCT,and CRP levels of the neonates in the two groups at different time points were compared,and the factors affecting the prognosis of neonates with sepsis were analyzed.Results:Among the 86 neonates with sepsis,there were 77 neonates in the cured/improved group and 9 neonates in the death group(4 neonates died within 12 hours,2 died within 2 days,2 died within 3 days,and 1 died within 5 days).The percentages of IL-6>7 pg/mL,PCT>0.5 ng/mL,and CRP>10 mg/mL in the death group were higher than those in the cured/improved group at 12 hours,12-36 hours,and 7 days after onset(P<0.05).There were no statistically sig-nificant differences in gender,premature rupture of membranes,preterm birth,jaundice,and delivery method between the two groups(P>0.05).The gestational age,birth weight,and Ages&Stages Questionnaires(ASQ)at 0-6 years old were significantly different between the two groups(P<0.05).Multivariate logistic regression analysis showed that ASQ at 0-6 years old,IL-6,PCT,and CRP were independent risk factors for the prognosis of neonatal sepsis(P<0.001).Conclusion:Serum IL-6,PCT,and CRP levels are related factors affecting the prognosis of neonates with sepsis.Monitoring serum IL-6,PCT,and CRP levels may pro-vide reliable references for clinical adjustment of treatment strategies for neonatal sepsis.

关 键 词：白介素-6 降钙素原 C反应蛋白 新生儿败血症 预后 

分 类 号：R722.131[医药卫生—儿科]