三维孔道结构的HA@Ag@ZIF-8@BG可降解支架的制备及性能  

Preparation and Performance of HA@Ag@ZIF-8@BG Degradable Scaffolds with Three-dimensional Pore Structure

作　　者：付彪 朱敏 FU Biao;ZHU Min(School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学材料与化学学院,上海200093

出　　处：《广州化学》2024年第2期46-51,I0003,共7页Guangzhou Chemistry

摘　　要：采用3D打印技术制备了生物活性玻璃(BG)支架,并通过1150℃烧结得到了纯BG支架。以金属有机框架(ZIF-8)、硝酸银、透明质酸(HA)为原料,采用原位生长和双溶剂的方法成功制备了不同组分的HA@Ag@ZIF-8@BG支架。利用Zeta、BET、XRD、FT-IR和SEM对材料的微观结构和性能进行了研究,探究了各组分支架的孔隙率、抗压强度以及降解能力。结果表明:原位生长未改变BG支架的原有三维孔道结构和孔隙率;支架的抗压强度仍处于人体松质骨力学强度范围;由于ZIF-8、Ag^(+)和HA的加入减缓了支架在14天内的降解,降解率维持在较低的8.5%左右,细胞生存的弱碱性环境未受影响,可促进细胞和新骨组织的生长。Bioactive glass(BG)scaffolds were prepared by 3D printing technology,and pure BG scaffolds were obtained by sintering at 1150°C.HA@Ag@ZIF-8@BG scaffolds with different components were successfully prepared using metal organic framework(ZIF-8),silver nitrate,and hyaluronic acid(HA)as raw materials by in situ growth and dual-solvent method.The microstructure and properties of the materials were investigated using Zeta,BET,XRD,FT-IR and SEM.The porosity,compressive strength,and degradability of each component scaffold were investigated.The results showed that in situ growth did not change the original three-dimensional pore structure and porosity of the BG scaffold.The compressive strength of the scaffolds is still in the range of the mechanical strength of human cancellous bone.As the addition of ZIF-8,Ag^(+)and HA slowed down the degradation of the scaffold within 14 days,the degradation rate was maintained at a low rate of about 8.5%and the weak alkaline environment for cell survival was not affected,which could promote the growth of cells and new bone tissue.

关 键 词：支架 3D打印 原位生长 骨组织 生物活性玻璃 

分 类 号：R318[医药卫生—生物医学工程]