归芍参芪地黄汤加减治疗慢性肾功能不全50例临床观察  

Clinical effect of modified Guishao Shenqi Dihuang decoction in treatment of chronic renal insufficiency:An analysis of 50 cases

作　　者：张才圣 陈良春 周婉双 段吾磊 彭堂智 黄艳 ZHANG Caisheng;CHEN Liangchun;ZHOU Wanshuang;DUAN Wulei;PENG Tangzhi;HUANG Yan(Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Changsha 410006,Hunan,China)

机构地区：[1]湖南省中西医结合医院,湖南长沙410006

出　　处：《湖南中医杂志》2024年第3期1-4,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省保健专项资金科研课题(B2021-08)。

摘　　要：目的:观察归芍参芪地黄汤加减治疗肝肾亏虚、瘀毒内结型慢性肾功能不全患者的临床疗效。方法:将100例肝肾亏虚、瘀毒内结型慢性肾功能不全患者,采用随机数字表法分为治疗组和对照组,每组各50例。对照组给予西医常规治疗,治疗组在对照组的基础上加用归芍参芪地黄汤加减治疗。2组均以1个月为1个疗程,共治疗3个疗程。比较2组综合疗效、中医证候积分、肾功能相关指标[血肌酐(Scr)、内生肌酐清除率(Ccr)、尿素氮(BUN)、胱氨酸蛋白酶抑制剂C(Cys-C)和24 h尿蛋白定量(U-TP/24 h)]和生活质量评分。结果:总有效率治疗组为78.00%(39/50),对照组为46.00%(23/50),2组比较,差异有统计学意义(P<0.01)。2组中医证候积分、肾功能各相关指标、生活质量评分治疗前后组内比较以及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:归芍参芪地黄汤加减可以改善肝肾亏虚、瘀毒内结型慢性肾功能不全患者的临床疗效,并提高其生活质量。Objective:To investigate the clinical effect of modified Guishao Shenqi Dihuang decoction in the treatment of chronic renal insufficiency with deficiency of liver and kidney and intermingled stasis and toxin.Methods:A total of 100 patients with chronic renal insufficiency with deficiency of liver and kidney and intermingled stasis and toxin were divided into treatment group and control group using a random number table,with 50 patients in each group.The patients in the control group received conventional Western medicine treatment,and those in the treatment group received modified Guishao Shenqi Dihuang decoction in addition to the treatment in the control group.Each course of treatment was 1 month,and both groups were treated for three courses.The two groups were compared in terms of overall response,traditional Chinese medicine(TCM)syndrome score,renal function parameters(serum creatinine,creatinine clearance rate,blood urea nitrogen,cystatin C,and 24-hour urinary pro-tein),and quality of life score.Results:There was a significant difference in overall response rate between the treatment group and the control group[78.00%(39/50)vs 46.00%(23/50),P<0.01].After treatment,both groups had significant changes in TCM syndrome score,renal function parameters,and quality of life score,and there were significant differences in these indicators between the two groups after treatment(P<0.05).Conclusion:Modified Guishao Shenqi Dihuang decoction can improve the treatment outcome and quality of life of patients with chronic renal insufficiency with deficiency of liver and kidney and intermingled stasis and toxin.

关 键 词：慢性肾功能不全 肝肾亏虚、瘀毒内结型 归芍参芪地黄汤加减 

分 类 号：R277.525[医药卫生—中医学]