淀粉样脑血管病相关心脏损伤的研究进展  

Research progress in cardiac injury associated with cerebral amyloid angiopathy

作　　者：吕汶彩 欧阳升[1] 李江娇 张志江 LYU Wencai;OUYANG Sheng;LI Jiangjiao;ZHANG Zhijiang(Department of Neurology,Baiyin First People's Hospital,Gansu Province,Baiyin730900,China)

机构地区：[1]甘肃省白银市第一人民医院神经内科,甘肃白银730900

出　　处：《中国当代医药》2024年第11期191-194,共4页China Modern Medicine

摘　　要：淀粉样脑血管病是在世界范围内普遍存在的一种疾病,在老年人阿尔茨海默病患者中更为常见,最终结果就是导致大脑多发微出血灶。其特征是淀粉样蛋白-β在大脑皮质和软脑膜血管壁沉积,可能通过激活星形胶质细胞、小胶质细胞和促炎症物质来诱导大脑慢性炎症状态,损伤血脑屏障的完整性。淀粉样脑血管病是老年人认知改变和脑内出血的主要原因,患者也经常伴有心脏损伤。淀粉样脑血管病造成的心脏损伤是一个新的研究领域,需要深入分析从而提供治疗及预防靶点。Cerebral amyloid angiopathy is a prevalent disease in the world,more common in elderly patients with Alzheimer's disease,and the end result is multiple microbleeding foci in the brain.It is characterized by the deposition of amyloid-βin the cerebral cortex and leptomeningeal blood vessel wall,which may induce the chronic inflammatory state of the brain and damage the integrity of the blood brain barrier by activating astrocytes,microglia,and pro-inflammatory substances.Cerebral amyloid angiopathy is the main cause of cognitive changes and intracerebral hemorrhage in the elderly,and patients are often associated with cardiac damage.Cardiac damage caused by cerebral amyloid angiopathy is a new area of research that requires in-depth analysis to provide therapeutic and preventive targets.

关 键 词：淀粉样脑血管病 淀粉样蛋白-β TAU蛋白 转甲状腺素淀粉样蛋白 心脏损伤 

分 类 号：R541[医药卫生—心血管疾病]