2型糖尿病视网膜病变不同时期血栓弹力图指标变化及临床意义分析  

Changes and Clinical Significance of Thromboelastogram Indexes in Different Periods of Type 2 Diabetic Retinopathy

作　　者：陈施婧 李冬琨 王菲 CHEN Shijing;LI Dongkun;WANG Fei(Department of Blood Transfusion,Changzhou Fourth People's Hospital,Changzhou,Jiangsu Province,213032 China;Department of Clinical Laboratory,Changzhou Fourth People's Hospital,Changzhou,Jiangsu Province,213032 China;Department of Nephrology,Changzhou Fourth People's Hospital,Changzhou,Jiangsu Province,213032 China)

机构地区：[1]常州市第四人民医院输血科,江苏常州213032 [2]常州市第四人民医院检验科,江苏常州213032 [3]常州市第四人民医院肾内科,江苏常州213032

出　　处：《糖尿病新世界》2024年第3期181-184,共4页Diabetes New World Magazine

摘　　要：目的探究分析2型糖尿病视网膜病变不同时期血栓弹力图指标变化及临床意义。方法选取2019年1月—2023年12月常州市第四人民医院诊治的86例2型糖尿病患者为研究对象,根据糖尿病视网膜病变(Diabetic Retinopathy,DR)严重程度,分为无视网膜病变组(NDR组,28例)、非增生期组(NPDR组,29例)、增生期组(PDR组,29例),对不同时期血栓弹力图指标变化及临床意义进行分析。结果3组R值、K值比较,NDR组>NPDR组>PDR组,差异有统计学意义(P均<0.05)。3组MA值比较,NDR组<NPDR组<PDR组,差异有统计学意义(P均<0.05)。NDR组、NPDR组、PDR组Angle值分别为(67.34±2.32)、(68.90±2.43)、(70.20±2.14)Deg,NDR组与NPDR组、NDR组与PDR组、NPDR组与PDR组比较,差异有统计学意义(t=2.501、2.477、2.163,P均<0.05)。结论不同时期2型糖尿病视网膜病变患者的各项血栓弹力图指标变化及临床意义各异,随着DR严重程度增加,R值、K值越低,且MA值、Angle值越高,对2型糖尿病视网膜病变的诊断具有一定的参考价值。Objective To explore and analyze the changes and clinical significance of thromboelastogram indexes in different periods of type 2 diabetic retinopathy.Methods A total of 86 patients with type 2 diabetes diagnosed and treated in Changzhou Fourth People's Hospital from January 2019 to December 2023 were selected as the study ob-jects.According to the severity of DR,they were divided into non-retinopathy group(NDR group,28 cases),non-proliferative stage group(NPDR group,29 cases)and proliferative stage group(PDR group,29 cases).The changes and clinical significance of thromboelastogram indexes in different periods were analyzed.Results R value and K value were compared among three groups,NDR group>NPDR group>PDR group,and the differences were statisti-cally significant(all P<0.05).MA value were compared among three groups,NDR group<NPDR group<PDR group,and the difference was statistically significant(all P<0.05).The Angle values of NDR group,NPDR group and PDR group were(67.34±2.32),(68.90±2.43)and(70.20±2.14)Deg,respectively,there was statistically significant differ-ence in the comparison between NDR group and NPDR group,NDR group and PDR group,NPDR group and PDR group(t=2.501,2.477,2.163,all P<0.05).Conclusion The changes and clinical significance of various thromboelas-ticity indexes in patients with type 2 diabetic retinopathy at different periods vary.With the increase of DR Severity,the lower the R value and K value,and the higher the MA value and Angle value,which have certain reference value for the diagnosis of type 2 diabetic retinopathy.

关 键 词：2型糖尿病视网膜病变 血栓弹力图指标 临床意义 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]