富马酸丙酚替诺福韦联合肝爽颗粒治疗慢性乙肝肝纤维化的疗效及对患者免疫功能和炎症状态的影响体会  

Effect of Profol Tenofovir Fumarate Combined with Ganshuang Granule on Chronic Hepatitis B Liver Fibrosis and Its Influence on Immune Func⁃tion and Inflammatory State of Patients

作　　者：刘英果 LIU Yingguo(Department of Hepatology,Liaocheng Infectious Disease Hospital,Liaocheng,Shandong Province,252000 China)

机构地区：[1]聊城市传染病医院肝病科,山东聊城252000

出　　处：《中外医疗》2024年第6期11-14,24,共5页China & Foreign Medical Treatment

摘　　要：目的分析对慢性乙肝肝纤维化患者实施富马酸丙酚替诺福韦、肝爽颗粒联合治疗对炎症状态、免疫功能、疗效的影响。方法方便选取2022年5月—2023年4月聊城市传染病医院收治的92例慢性乙肝肝纤维化患者为研究对象,以抽签方法分为两组,对照组(46例)施以富马酸丙酚替诺福韦治疗,治疗组(46例)施以富马酸丙酚替诺福韦联合肝爽颗粒治疗,分析和对比两组治疗效果。结果治疗组治疗总有效率为95.65%,高于对照组的76.09%,差异有统计学意义(χ^(2)=5.733,P=0.017)。治疗后,治疗组炎症状态明显轻于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组免疫功能指标优于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组肝纤维化指标优于对照组,差异有统计学意义(P<0.05)。治疗后,两组肝功能指标较治疗前改善,但两组比较,差异无统计学意义(P>0.05)。结论对慢性乙肝肝纤维化患者实施富马酸丙酚替诺福韦、肝爽颗粒联合治疗效果良好,可改善炎症状态、免疫功能、肝纤维化、肝功能指标,具有临床应用价值。Objective To analyze the effects of profol and tenofovir fumarate combined with Ganshuang granule on in-flammatory state,immune function and curative effect in patients with chronic hepatitis B liver fibrosis.Methods 92 patients with chronic hepatitis B liver fibrosis admitted to Liaocheng Infectious Disease Hospital from May 2022 to April 2023 were conveniently selected as the study objects and divided into two groups by drawing lot.The control group(46 cases)was treated with profofovir fumarate and tenofovir pofofovir fumarate and the treatment group(46 cases)was treated with profofovir fumarate and tenofovir combined with Ganshuang granules.The therapeutic effects of the two groups were analyzed and compared.Results The total effective rate of the treatment group was 95.65%,higher than that of the control group(76.09%),and the difference was statistically significant(χ^(2)=5.733,P=0.017).Af-ter treatment,the inflammation in the treatment group was significantly less than that in the control group,and the dif-ference was statistically significant(P<0.05).After treatment,the immune function index of the treatment group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the liver fibrosis indexes in the treatment group were better than those in the control group,and the differences were statisti-cally significant(P<0.05).After treatment,liver function indexes in both groups were improved compared with those before treatment,However,there was no significant difference between the two groups(P>0.05).Conclusion The com-bination of profol and tenofovir fumarate and Ganshuang granule in the treatment of chronic hepatitis B liver fibrosis has a good effect,which can improve the inflammatory state,immune function,liver fibrosis and liver function in-dexes,and it has clinical application value.

关 键 词：慢性乙肝肝纤维化 肝爽颗粒 富马酸丙酚替诺福韦 炎症状态 免疫功能 

分 类 号：R512.62[医药卫生—内科学]