γδ T细胞在结核免疫中的作用  

The role ofγδT cells in tuberculosis immunity

作　　者：宋亚敏 魏婧 郭方正 李柏青 汪洪涛[1,2,3] 许涛 SONG Yamin;WEI Jing;GUO Fangzheng;LI Baiqing;WANG Hongtao;XU Tao(Laboratory Center of Laboratory Medicine,College of Laboratory Medicine,Bengbu Medical College,Bengbu 233030,China;Anhui Province Key Laboratory of Basic and Clinical Immunology of Chronic Diseases,Bengbu Medical College,Bengbu 233030,China;Department of Immunology,College of Laboratory Medicine,Bengbu Medical College,Bengbu 233030,China;Department of Clinical Laboratory Diagnostics,College of Laboratory Medicine,Bengbu Medical College,Bengbu 233030,China)

机构地区：[1]蚌埠医学院检验医学院检验医学实验中心,蚌埠233030 [2]蚌埠医学院慢性疾病免疫学基础与临床安徽省重点实验室,蚌埠233030 [3]蚌埠医学院检验医学院免疫学教研室,蚌埠233030 [4]蚌埠医学院检验医学院临床检验诊断学教研室,蚌埠233030

出　　处：《生命的化学》2024年第3期431-440,共10页Chemistry of Life

基　　金：安徽省自然科学基金项目(1908085MH252,2008085QH405);慢性疾病免疫学基础与临床安徽省重点实验室开放课题基金项目(KLICD-2002-Z3);呼吸系病临床基础安徽省重点实验室开放课题基金项目(HX2022-Z02);蚌埠医学院“512人才培育计划”项目(by51201309);蚌埠医学院研究生科研创新计划项目(Byycx22013,Byycx23078)。

摘　　要：T细胞是执行固有免疫功能的T细胞,其T细胞表面受体(T cell receptor,TCR)由γ和δ链组成,连接固有免疫和适应性免疫。γδ T细胞不依赖主要组织相容性复合物(major histocompatibility complex,MHC),不需抗原提呈细胞(antigen-presenting cells,APC)的提呈,直接识别并结合抗原分子。γδ T细胞在结核免疫中发挥重要作用。本文就γδ T细胞免疫功能及其在抗结核免疫中的作用进行综述,旨在为γδ T细胞抗结核细胞免疫治疗与疫苗开发等提供新的思路。γδT cells are T cells that perform intrinsic immune functions,and their T cell receptor(TCR)consists ofγandδchains that link intrinsic and adaptive immunity.γδT cells are not dependent on the major histocompatibility complex(MHC)and do not require the presentation of antigen-presenting cells(APC)to recognize and bind antigenic molecules directly.γδT cells have been found to play an important role in tuberculosis immunity.This paper reviews the immune function ofγδT cells and their role in anti-tuberculosis immunity,aiming to provide new ideas forγδT cell anti-tuberculosis cellular immunotherapy,and vaccine development.

关 键 词：ΓΔT细胞 结核病 抗菌免疫 治疗方法 

分 类 号：R392[医药卫生—免疫学]