调控睡眠-觉醒的分子细胞和脑网络机制探讨  

Review on the molecular,cellular and circuit-level mechanisms of sleep-wake regulation

作　　者：尹楚慧 高稚凡 刘晏君 杜镜鉴 余立晗 曾燕[1,2] 梅宇飞 YIN Chu-Hui;GAO Zhi-Fan;LIU Yan-Jun;DU Jing-Jian;YU Li-Han;ZENG Yan;MEI Yu-Fei(Brain Science and Advanced Technology Institute,Wuhan University of Science and Technology,Wuhan 430065,China;Hubei Province Key Laboratory of Occupational Hazard Identification and Control,Wuhan 430065,China;Wuhan University of Science and Technology Medical School,Wuhan 430065,China)

机构地区：[1]武汉科技大学脑科学先进技术研究院,武汉430065 [2]职业危害识别与控制湖北省重点实验室,武汉430065 [3]武汉科技大学医学院,武汉430065

出　　处：《生命科学》2024年第3期399-410,共12页Chinese Bulletin of Life Sciences

基　　金：武汉科技大学大学生创新创业训练计划项目(22Z106);职业危害识别与控制湖北省重点实验室开放基金项目(0HIC2021Z07);国家自然科学基金青年项目(82201351)。

摘　　要：睡眠是影响人体健康的重要因素,睡眠失调易引起多种生理和心理疾病。睡眠稳态既受外界因素(昼夜变化、饮食和温度)影响,亦受内在系统(分子钟和促睡眠/觉醒神经元)调控。细胞内有CLOCK、PER、CRY、NPAS2和BMAL1等分子周期性变化控制生物节律;脑内有基底前脑、丘脑、下丘脑、脑桥和延髓等神经元群体特异性地抑制或促进睡眠与觉醒,各核团之间通过突触连接形成神经网络启动和维持觉醒、非快速眼动睡眠和快速眼动睡眠。睡眠障碍普遍存在,本综述将针对调控生物体睡眠-觉醒的分子、细胞和脑网络机制展开讨论,为防治睡眠障碍类疾病提供新的思路。Sleep is an important contributing factor for human health,sleep disorders are prone to cause a variety of physiological and psychological diseases.Sleep homeostasis is influenced by both external factors(circadian rhythm,diet and temperature)and intrinsic systems(molecular clock and sleep/wake prompting neurons).Within the cell,intracellular molecules such as CLOCK,PER,CRY,NPAS2 and BMAL1 modulate circadian rhythm.Secondly,neuronal assemblies in the basal forebrain,thalamus,hypothalamus,pons,and medulla oblongata specifically inhibit or initiate sleep and wakefulness;neuronal assemblies connect with synaptic connections that specifically regulate the initiation and maintenance of wakefulness,non-rapid eye movement sleep and rapid eye movement sleep.Sleep disorders are commonly existed in people with irregular lifestyles.In this review,we discuss the molecular,cellular and neural circuit mechanisms underlying sleep-wakefulness regulation,which will provide new insights for sleep-disorder diseases.

关 键 词：睡眠 觉醒 脑网络 昼夜节律 快速眼动睡眠 

分 类 号：Q428[生物学—神经生物学] R338[生物学—生理学]