抗GABABR脑炎四例  

Anti-GABABR encephalitis and(report of 4 cases)

作　　者：陈晓莉[1] 张国平[2] 王群 李静[3] 杨燕芳 Chen Xiaoli;Zhang Guoping;Wang Qun;Li Jing;Yang Yanfang(Department of Neurology,Shaanxi Provincial People's Hospital,Xi'an 710008,China)

机构地区：[1]陕西省人民医院神经内二科,西安710008 [2]陕西省人民医院CT室 [3]中南大学湘雅医院神经内科 [4]上海市监狱总医院内科

出　　处：《脑与神经疾病杂志》2024年第5期271-275,共5页Journal of Brain and Nervous Diseases

基　　金：国家自然科学基金面上项目(81471225);湖南省发改委计划项目[2021]212号40。

摘　　要：目的抗γ氨基丁酸B型受体(GABABR)脑炎四例,以减少临床误诊误治。方法收集4例曾初诊为其他疾病的抗GABABR脑炎的临床资料,并分析其临床特征及误诊原因。结果4例患者均有癫痫发作及认知障碍,2例(例2、例4)伴发精神症状。4例颅脑MRI均发现单侧或双侧颞叶病变。初步诊断分别为胶质瘤3例和短暂性脑缺血发作1例(例4)。误诊时间为12~68d。结论抗GABABR脑炎的临床特征与其他疾病存在交叉,提高对该疾病的认识、尽早完善特异性抗体检查是明确诊断的关键,从而减少临床误诊误治。Objective To review the cases of anti-gamma-aminobutyric acid B-type receptor(GABABR)encephalitis in order to reduce clinical misdiagnosis and mistreatment.Methods The clinical data of 4 cases of anti-GABABR encephalitis misdiagnosed as other diseases were collected and analyzed.Results All the 4 patients had epileptic seizure and cognitive impairment,including 2 patients(case 2,case 4)with psychiatric symptoms.Unilateral or bilateral temporal lobe lesions were found in all the 4 cases.The preliminary diagnosis was glioma in 3 cases and transient ischemic attack in 1 case(case 4).The misdiagnosis time was 12-68 days.Conclusion The clinical manifestations and auxiliary examination of Anti-GABABR encephalitis overlap with other diseases.Improving the understanding of the disease and perfecting the specific antibody examination as soon as possible are the key to avoid misdiagnosis.

关 键 词：抗γ氨基丁酸B型受体 磁共振成像 胶质瘤 短暂性脑缺血发作 

分 类 号：R512.3[医药卫生—内科学]