Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp^(3) C—H Bonds with Iodine(III)  

作　　者：Hao Jia Nan Li Chunmei Tang Yajuan Wang Yonghao Xi Rongbao Liao Wei Xu Fufang Wu Xiaobao Shen Hongbin Zhai 

机构地区：[1]Biomass Oligosaccharides Engineering Technology Research Center of Anhui Province,Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions,Fuyang Normal University,Fuyang,Anhui,236037 China [2]Institute of Marine Biomedicine,Shenzhen Polytechnic,Shenzhen,Guangdong,518055 China [3]State Key Laboratory of Chemical Oncogenomics,Shenzhen Engineering Laboratory of Nano Drug Slow-Release,Peking University Shenzhen Graduate School,Shenzhen,Guangdong,518055 China

出　　处：《Chinese Journal of Chemistry》2024年第5期505-510,共6页中国化学（英文版）

基　　金：supported the Natural Science Foundation of Higher Education Institutions in Anhui Province(2022AH030133,2022AH051340);National Natural Science Foundation of China(22231003,22271008);Shenzhen Science and Technology Program(Grant No.KQTD20190929174023858);Shenzhen Science and Technology Innovation Committee(GXWD20201231165807007-20200812100115001);Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2023SHIBS0004);Horizontal Cooperation Project of Fuyang Municipal Government(SXHZ202201);Key Projects of the Support Program for Outstanding Young Talents in Anhui Province Colleges and Universities(gxyqZD2020030);Yifan Pharmaceutical Co.,Ltd.(HX2019033);Innovative Drug Design&Development Collaborative Team(TDYY2021009).

摘　　要：A metal-free,green,and sustainable functionalization of unactivated alkyl sp^(3) C—H bonds is reported using iodine(III)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alcohols,and ketones could be constructed by addition of different coupling reagents.Cheap and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp^(3) C—H bond in a highly efficient manner,which can construct different alkylation products by adding corresponding coupling reagents.

关 键 词：Alkyl sp^(3)C—H bonds Chlorination BROMINATION OXIDATION Iodine(III) C—H activation Radical Photocatalysis 

分 类 号：O621.25[理学—有机化学]