Nickel-Catalyzed Stereoselective Migratory Carboboration of 1,4-Cyclohexadiene  

作　　者：Yaoyu Ren Lujin Wang Chao Ding Yangyang Li Guoyin Yin 

机构地区：[1]The Institute for Advanced Studies,Wuhan University,Wuhan,Hubei,430072 China

出　　处：《Chinese Journal of Chemistry》2024年第4期356-362,共7页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22122107).

摘　　要：Multi-substituted cyclohexanes play a crucial role as scaffolds in bioactive compounds.While significant progress has been made in synthesizing substituted cyclohexanes,methods for the stereoselective assembly of 1,3-disubstituted cyclohexanes remain scarce.This study presents a novel approach involving nickel catalysis to achieve stereoselective carboboration of 1,4-cyclohexadiene.This innovative process allows for the simultaneous introduction of a boron group and an aryl or an alkyl fragment into the 1,4-cyclohexadiene framework under mild conditions,with exclusive regioselectivity and excellent cis configuration.The resulting products feature a double carbon bond and the incorporation of the boron group,offering significant potential for subsequent transformations and downstream applications.

关 键 词：1 4-Cyclohexadiene Carboboration NICKEL Chain-walking STEREOSELECTIVITY Difunctionalization 

分 类 号：O62[理学—有机化学]