肠道共生微生物脂质代谢物的黏膜免疫调节功能与机制  

Mucosal Immunomodulatory Function and Mechanism of Gut Commensal Microorganism-Derived Lipid Metabolites

作　　者：王亚婷 张浩浩 谢亚栋 宋昕阳 WANG Yating;ZHANG Haohao;XIE Yadong;SONG Xinyang(State Key Laboratory of Cell Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China)

机构地区：[1]细胞生物学国家重点实验室,中国科学院分子细胞科学卓越创新中心/生物化学与细胞生物学研究所,上海200031

出　　处：《中国细胞生物学学报》2024年第3期378-390,共13页Chinese Journal of Cell Biology

基　　金：国家重点研发计划(批准号:2022YFA0807300,2023YFA1800200);国家自然科学基金(批准号:32270945)资助的课题。

摘　　要：机体的肠道黏膜表面存在着大量与宿主免疫系统互作的共生微生物,其所编码的代谢通路可产生多种具有免疫调节活性的小分子物质。膳食脂肪可经脂解作用形成游离脂肪酸,并在肠道胆汁酸的协助下作为必需营养元素被机体所吸收利用。与此同时,肠道共生微生物既可将宿主来源的胆汁酸转化为多种脱结合胆汁酸或次级胆汁酸,也可将部分膳食来源的长链不饱和脂肪酸代谢为多种异构衍生物。目前,关于肠道共生微生物介导的脂质代谢网络调控宿主黏膜免疫系统发育、成熟与功能的研究方兴未艾。结合该实验室的相关研究,该文将对共生微生物脂质代谢物与肠道黏膜免疫互作机制的前沿进展进行综述与讨论。Trillions of symbiotic microorganisms interact with the host immune system on the surface of the intestinal mucosa.Their encoded microbial metabolic pathways can produce a variety of small molecules with immunomodulatory activities.Dietary fats undergo lipolysis to release free FAs(fatty acids).These FAs are then absorbed and utilized by the body as essential nutrients with the assistance of gut BAs(bile acids).Meanwhile,intestinal symbiotic microorganisms can convert host-derived BAs into deconjugated BAs or secondary BAs,and modify unsaturated long-chain FAs into various intestinal FA isomers.Research into how microbial lipid metabolic networks modulate the development,maturation,and function of our mucosal immune system is emerging.With this teams’relevant studies,this review will summarize and discuss the recent progress of mechanistic insights on the interaction between microbial lipid metabolites and gut mucosal immunity.

关 键 词：肠道黏膜免疫 共生微生物 脂质代谢物 

分 类 号：R392[医药卫生—免疫学]