GPR171的研究进展  

Research Progress of GPR171

作　　者：孔雪 谢欣 段彦辉[1] KONG Xue;XIE Xin;DUAN Yanhui(Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310000,China;Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China)

机构地区：[1]国科大杭州高等研究院,杭州310000 [2]中国科学院上海药物研究所,上海201203

出　　处：《中国细胞生物学学报》2024年第3期526-532,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:82160096,82260720)资助的课题。

摘　　要：GPR171是新近脱孤的一种G蛋白偶联受体,在中枢神经系统及免疫相关组织中表达水平较高。关于GPR171功能的相关研究不多,已有研究发现其在控制摄食、情绪和疼痛等神经系统功能以及调节肿瘤免疫、病毒感染等方面具有一定的作用,并且GPR171与GPR83很有可能通过相互作用调节受体功能。该文总结了GPR171的特性、配体,及其在中枢神经系统和免疫系统中的功能以及GPR171与其他受体的关系,为GPR171的功能研究及相关靶向药物开发提供了参考。GPR171,a recently deorphanized G protein-coupled receptor,is highly expressed in the CNS(central nervous system)and in immune-related tissues.Limited studies have been conducted on the function and activation mechanisms of GPR171,but GPR171 has been found to play regulatory roles in multiple aspects of the central nervous system,including food intake,mood and pain.Additionally,it is also implicated in the immune defense against tumors and viral infections.Furthermore,GPR171 and GPR83 may modulate receptor function throught interaction.This review summarizes the receptor’s currently known characteristics,ligands,and functions of GPR171,both in the central nervous system and immune system that can be a valuable reference to facilitate further research on the functional study of GPR171 as well as the development of targeted drugs.

关 键 词：GPR171 G蛋白偶联受体 中枢神经系统 免疫系统 

分 类 号：R346[医药卫生—基础医学]