TCR CDR3组库及HLA等位基因与新型冠状病毒肺炎关系的研究概况和进展  

Research progress and overview on the relationships between TCR CDR3 repertoire characteristics and the composition of HLA alleles with COVID-19

作　　者：周得维 李俊 李洋洋 姚新生 ZHOU De-wei;LI Jun;LI Yang-yang;YAO Xin-sheng(Department of Immunology Laboratory,Zunyi Medical University,Zunyi 563000,China;Department of Laboratory Medicine,The Third Affiliated Hospital of Zunyi Medical University/The First People's Hospital of Zunyi,Zunyi 563000,China)

机构地区：[1]遵义医科大学免疫学教研室,遵义563000 [2]遵义医科大学第三附属医院/遵义市第一人民医院检验科,遵义563000

出　　处：《现代免疫学》2024年第2期152-157,169,共7页Current Immunology

基　　金：国家自然科学基金地区科学基金项目(82160279,81860300);贵州省百层次人才基金([2018]5637)。

摘　　要：新型冠状病毒肺炎(corona virus disease 2019,COVID-19)是由严重急性呼吸系统综合征冠状病毒2型(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染所致。机体抗病毒的适应性免疫应答主要依赖T细胞选择性地清除病毒感染宿主细胞,而T细胞受体(T cell receptor,TCR)的结构决定其对病毒抗原决定簇的特异性识别,感染者TCR互补决定区3(complementarity determining region 3,CDR3)组库的特征在COVID-19的发生与发展中有重要的提示意义。此外,人类白细胞抗原(human leukocyte antigen,HLA)是不同个体对抗原引起免疫应答差异的主要原因,在人体的免疫应答中发挥着重要作用。文章重点概述TCR CDR3组库的特征和HLA等位基因的组成与COVID-19之间关系的研究概况和进展。Corona virus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has become a global health emergency.Adaptive immune response plays a critical role in clearing virus-infected host cells,mainly relying on T cells.The structure of the T cell receptor(TCR)determines the specificity of viral antigen cluster recognition,and the characteristics of the TCR complementarity determining region 3(CDR3)repertoire of infected individuals have indications for the occurrence and development of COVID-19 disease.Additionally,human leukocyte antigen(HLA)gene is the main factor responsible for individual varieties in immune responses to antigens and plays an important role in human immune responses.This review focuses on the research progress and overview of the relationships of TCR CDR3 repertoire characteristics and of the composition of host HLA alleles with COVID-19.

关 键 词：新型冠状病毒肺炎 T细胞受体互补决定区3组库 严重急性呼吸系统综合征冠状病毒2型 人类白细胞抗原 

分 类 号：R392.11[医药卫生—免疫学]