TNF-α及其拮抗剂在生殖免疫性疾病中的诊疗价值  

The clinical value of TNF-α and its antagonists in reproductive immune diseases

作　　者：汪娟 王晨 黄进格 牟方祥 王芳[2] WANG Juan;WANG Chen;HUANG Jin-ge;MOU Fang-xiang;WANG Fang(College of Integrated Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Reproductive Medicine,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]甘肃中医药大学中西医结合学院,兰州730000 [2]兰州大学第二医院生殖医学科,兰州730030

出　　处：《现代免疫学》2024年第2期180-184,共5页Current Immunology

基　　金：兰州大学第二医院项目(YJS-BD-19);兰州大学项目(071100132)。

摘　　要：TNF-α是免疫细胞和胎盘细胞分泌的促炎性Th1型细胞因子,在调节胚胎着床、胎盘形成和最终妊娠结局的炎症及免疫机制中发挥重要作用。妊娠早期TNF-α的适度增加或对胚胎着床有益,但其过度表达会通过不同的途径和通路介导生殖免疫性疾病的发生,最终导致不良孕产结局。近年来,TNF-α在生殖免疫性疾病中的临床应用成为了生殖医学界关注的焦点:TNF-α能否作为生殖免疫性疾病的常规筛查靶标,TNF-α拮抗剂能否改善妊娠结局,短期/长期用药对母胎而言是否安全,这些都值得深入思考。基于上述问题,该文就TNF-α及其拮抗剂在生殖免疫性疾病中的诊疗价值展开综述,以期为临床提供新的诊疗思路。TNF-α is a pro-inflammatory Th1-type cytokine secreted by immune and placental cells,which plays important roles in regulating the inflammatory and immune mechanisms of embryo implantation,placentation,and final pregnancy outcome.Moderate increase of TNF-α in early pregnancy may be beneficial to embryo implantation.However,over-expression of TNF-α can lead to the occurrence of reproductive immune diseases through different pathways,and cause unexpected pregnancy and birth outcomes.In recent years,the clinical application of TNF-α in reproductive immune diseases has become a hotspot in reproductive medicine.Nonetheless,questions on whether TNF-α can be used as a routine screening target for reproductive immune diseases,whether TNF-α antagonists can improve pregnancy outcomes,or whether short-term/long-term use of TNF-α is safe for mother and fetus are required to be carefully considered.Based on above questions,this review discusses the value of TNF-α and its antagonists on the diagnosis and treatment of reproductive immune diseases,for providing new ideas to develop clinical diagnosis and treatment strategies.

关 键 词：肿瘤坏死因子Α 肿瘤坏死因子α拮抗剂 生殖免疫 诊疗价值 

分 类 号：R456[医药卫生—治疗学]