Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in China  

作　　者：Sayed Salman Zeeshan Umar Yonghong Xiao 

机构地区：[1]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,the First Afiliated Hospital College of Medicine,Zhejiang University,Hangzhou 310000,China [2]Marshall Laboratory of Biomedical Engineering,School of Medicine,Shenzhen University,Shenzhen 510000,China

出　　处：《Biosafety and Health》2024年第1期40-49,共10页生物安全与健康（英文）

摘　　要：Extended‐spectrumβ‐lactamase(ESBL)‐producing Escherichia coli(E.coli)are widespread in China,with occurrences documented in humans,animals,and the environment.The dissemination of ESBL‐producing E.coli is likely facilitated by the widespread use of antibiotics in human and animal agriculture,the presence of antibiotic‐resistant bacteria(ARBs)in animal feces,and close human‐animal interactions.Plasmids,particularly those belonging to incompatibility(Inc)group,such as IncF,IncI,and IncH families,play a vital role in facilitating the horizontal gene transfer of ESBL genes across various sectors,from humans to animals and the environment.IS 26 and IS 1 elements also significantly influences the mobilization and evolution of antibiotic‐resistance genes(ARGs),contributing to the spread of ESBL‐producing E.coli.blaCTX‐M-14,blaCTX-15,and blaCTX‐M-55 are prevalent in ESBL‐producing E.coli across the three domains and are often found in con-junction with other ARGs.Considering these challenges,it is imperative to take proactive measures to prevent the further spread of ARBs.This includes the judicious and responsible use of antibiotics and efforts to mini-mize contact with animal feces.Sector‐specific strategies should be developed to effectively educate and engage relevant personnel in tackling this multifaceted problem.These efforts are vital to combat the dissem-ination of ESBL‐producing E.coli and preserve public health.

关 键 词：Escherichia coli Extended‐spectrumβ‐lactamases CTX‐M 

分 类 号：R516[医药卫生—内科学]