西藏拉萨地区住院2型糖尿病患者合并高尿酸血症的患病率及影响因素分析  

Prevalence and influencing factors of hyperuricemia in hospitalized patients with type 2 diabetes mellitus in Lhasa,Xizang

作　　者：魏静茹 吕雪梅[2] Wei Jingru;Lv Xuemei(Medical School of Xizang University,Lhasa 850000,China;People's Hospital of Xizang Autonomous Region,Lhasa 850000,China)

机构地区：[1]西藏大学医学院,拉萨850000 [2]西藏自治区人民医院,拉萨850000

出　　处：《西藏科技》2024年第3期52-56,共5页Xizang Science And Technology

摘　　要：目的了解西藏某三甲医院2型糖尿病(T2DM)住院患者合并高尿酸血症患病率及影响因素的分析。方法搜集西藏自治区人民医院内分泌科2022年1月1日—2022年12月31日T2DM住院患者271例,根据内分泌科T2DM住院患者血尿酸水平分为观察组,对照组。观察组:2型糖尿病合并高尿酸组(HUA);对照组:2型糖尿病非合并高尿酸组(NUA),搜集两组T2DM住院患者一般临床资料,包括年龄、性别、体重指数(BMI)、血尿酸(UA)、甘油三酯(TG)、总胆固醇(TC)、血红蛋白(Hb)、糖化血红蛋白(HbA1c)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、肾小球滤过率(GFR)以及吸烟史、饮酒史、高血压病史,用SPSS 27.0统计学软件进行统计分析。结果观察组患者BMI、血红蛋白高于对照组,其糖化血红蛋白、高密度脂蛋白、肾小球滤过率低于对照组,组间比较差异具有统计学意义(P<0.05)。logistic回归分析结果:血红蛋白、糖化血红蛋白、BMI及年龄是HUA危险因素。结论该研究结果示西藏某三甲医院T2DM住院患者高尿酸血症患病率约为32%,2型糖尿病患者患高尿酸血症危险因素有:血红蛋白、糖化血红蛋、BMI、肾小球滤过率及年龄,临床2型糖尿病患者根据危险因素应早实施预防措施,降低高尿酸血症发生可能。Objective To understand the prevalence and influencing factors of hyperuricemia in inpatients with type 2 diabetes mellitus(T2DM)in a tertiary hospital in Xizang.Methods A total of 271 patients with T2DM in the Department of Endocrinology of the People's Hospital of Xizang Autonomous Region from January 1,2022 to December 31,2022 were collected and they were divided into observation group and control group according to the blood uric acid level of these inpatients.The observation group is the T2DM with high uric acid group(HUA),while the control group is the T2DM of non-concomitant hyper uric-acid group(NUA).The general clinical data of two groups of inpatients with T2DM were collected,including age,gender,body mass index(BMI),serum uric acid(UA),triglyceride(TG),total cholesterol(TC),hemoglobin(Hb),glycosylated hemoglobin(HbA1c),low-density lipoprotein(LDL-C),high density lipoprotein(HDL-C),glomerular filtration rate(GFR)and smoking history,alcohol consumption history and hypertension history.These data went through statistical analysis performed by the SPSS 27.0 statistical software.Results The BMI and hemoglobin of the observation group were higher than those of the control group,while the HbA1c,HDL and GFR of the patients in the observation group were lower than control group,and the differences between the groups were statistically significant(P<0.05).Logistic regression analysis shows that HbA1c,BMI and age were risk factors for HUA.Conclusion The results of this study showed that the prevalence of hyperuricemia in T2DM inpatients in a tertiary hospital in Xizang was about 32%.Risk factors for hyperuricemia in patients with type 2 diabetes mellitus include Hb,HbA1c,BMI,GFA and age.Patients with clinical type 2 diabetes mellitus should take preventive measures as early as possible according to the risk factors so as to reduce the possibility of hyperuricemia.

关 键 词：西藏 2型糖尿病 高尿酸血症 患病率 影响因素 

分 类 号：R587.1[医药卫生—内分泌] R589.7[医药卫生—内科学]