不同剂量阿司匹林联合复合维生素片在子痫前期高危孕妇中的预防效果及安全性研究  

Preventive effect and safety of different dose aspirin combined with multivitamin tablets in pregnant women at high risk of preeclampsia

作　　者：何续芳[1] 万艳 郭艳阳 赵玉荣[1] HE Xu-fang;WAN Yan;GUO Yan-yang;ZHAO Yu-rong(Department of Obstetrics,Fuxing Hospital,Capital Medical University,Beijing 100000;Department of Obstetrics and Gynecology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050;Department of Obstetrics and Gynecology,Yongledian Community Health Service Center,Tongzhou District,Beijing 101105,China)

机构地区：[1]首都医科大学附属复兴医院产科,北京100000 [2]首都医科大学附属北京友谊医院妇产科,北京100050 [3]北京市通州区永乐店社区卫生服务中心妇产科,北京101105

出　　处：《川北医学院学报》2024年第4期498-501,510,共5页Journal of North Sichuan Medical College

基　　金：北京市西城区优秀人才培养资助项目[拔尖团队(202048)]。

摘　　要：目的:探讨应用不同剂量阿司匹林联合复合维生素片在子痫前期高危孕妇中的预防效果及安全性。方法:选取180例子痫前期高危孕妇作为研究对象,所有患者给予阿司匹林及复合维生素片进行预防,并根据阿司匹林用药剂量分为低剂量组、中剂量组及高剂量组,每组各60例。记录并比较各组孕妇子痫前期发生率、凝血功能、血压、炎症反应、氧化应激及血管内皮功能情况。结果:子痫前期发生率阿司匹林低剂量组为13.33%,中剂量组为3.33%,高剂量组为15.00%,中剂量组低于低剂量组及高剂量组(P<0.05)。给药后,中剂量组及高剂量组D-二聚体(D-D)水平均低于低剂量组,凝血活酶时间(APTT)及凝血酶原时间(PT)水平均高于低剂量组(P<0.05)。给药后,中剂量组及高剂量组舒张压(DBP)、收缩压(SBP)、白细胞介素-6(IL-6)及血小板/淋巴细胞比率(PLR)水平均低于低剂量组,且中剂量组DBP水平低于高剂量组(P<0.05)。给药后,中剂量组及高剂量组丙二醛(MDA)及内皮素(ET-1)水平均低于低剂量组,超氧化物歧化酶(SOD)水平均高于低剂量组(P<0.05)。中剂量组不良妊娠结局发生率低于低剂量组及高剂量组(P<0.05)。结论:给予子痫前期高危孕妇每天每次100 mg的阿司匹林联合复合维生素片进行预防,可有效改善孕妇血压水平,利于调节凝血功能及控制炎症反应,从而有效降低子痫前期的发生,并改善孕妇妊娠结局。Objective:To investigate the preventive effect and safety of applying different doses of aspirin combined with multivitamin tablets in pregnant women at high risk of preeclampsia.Methods:A total of 180 high-risk pregnant women with preeclampsia were included as the subjects,and aspirin and multivitamin tablets were given to all the inclusion subjects for prophylaxis and divided into low-dose group,medium-dose group,and high-dose group according to the dosage of aspirin used,with 60 cases each group.The incidence of preeclampsia,coagulation,blood pressure,inflammatory response,oxidative stress,and vascular endothelial function in all three groups were recorded and compared.Results:The incidence of preeclampsia was 13.33%in low-dose aspirin group,3.33%in medium-dose aspirin group and 15.00%in high-dose aspirin group,and the medium-dose aspirin group was lower than that in low-dose aspirin group and high-dose aspirin group(P<0.05).After administration,D-dimer(D-D)levels were lower and prothrombin time(APTT)and prothrombin time(PT)levels in both the medium-dose and high-dose groups were higher than those in the low-dose group(P<0.05).After administration,the levels of diastolic blood pressure(DBP),systolic blood pressure(SBP),interleukin-6(IL-6),and platelet/lymphocyte ratio(PLR)in both the medium-dose and high-dose groups were lower than those in the low-dose group,and the level of DBP in the medium-dose group was lower than that in the high-dose group(P<0.05).After administration,the levels of malondialdehyde(MDA)and endothelin(ET-1)were lower and the levels of superoxide dismutase(SOD)in both the medium-dose and high-dose groups were higher than those in the low-dose group(P<0.05).The incidence of adverse pregnancy outcomes in the medium-dose group was lower than that in the low-dose and high-dose groups(P<0.05).Conclusion:The administration of 100 mg/daily aspirin combined with multivitamin tablets for prevention in pregnant women at high risk of preeclampsia can effectively improve maternal blood pressure levels

关 键 词：不同剂量 阿司匹林 复合维生素片 子痫前期 妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学]