腰椎间盘突出伴坐骨神经痛患者血清HIF-1α、VEGFA水平与痛阈值关系及交互作用  

Relationship and interaction between serum hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor A(VEGFA)and pain threshold in lumbar disc herniation with sciatica(LDHS)

作　　者：张雪峰 李伟[2] 王士源 袁光海 ZHANG Xuefeng;LI Wei;WANG Shiyuan;YUAN Guanghai(Department of Orthopedics,Qingdao Eighth People′s Hospital,Qingdao Shandong 266100,China)

机构地区：[1]青岛市第八人民医院骨科,山东青岛266100 [2]青岛市第八人民医院手足外科,山东青岛266100

出　　处：《新疆医科大学学报》2024年第4期542-547,共6页Journal of Xinjiang Medical University

基　　金：山东省重点研发计划项目(2022GSF31685)。

摘　　要：目的探讨腰椎间盘突出伴坐骨神经痛(LDHS)患者血清缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子A(VEGFA)水平与痛阈值的关系及交互作用。方法选取2020年5月至2023年2月在本院就诊的126例LDHS患者作为病例组,另选取同期126例体检健康者作为对照组。比较两组血清HIF-1α、VEGFA水平、痛阈值,Pearson相关系数分析血清HIF-1α、VEGFA水平与痛阈值的关系,多元线性回归分析血清HIF-1α、VEGFA水平与LDHS患者痛阈值的关系及交互作用。结果病例组血清HIF-1α、VEGFA水平高于对照组,痛阈值低于对照组(P<0.05)。病例组血清HIF-1α(r=0.777,P<0.001)、VEGFA(r=0.822,P<0.001)水平与痛阈值呈中度正相关,对照组血清HIF-1α(r=0.383,P<0.001)、VEGFA(r=0.453,P<0.001)水平与痛阈值无明显相关性。不考虑交互作用,血清HIF-1α、VEGFA水平与痛阈值存在线性相关(P<0.05),拟合方程为Y=-0.409+0.004×HIF-1α+0.019×VEGFA,所有预测变量可解释因变量的74.3%的方差。考虑交互作用,痛阈值的拟合方程为Y=19.276+0.062×HIF-1α+0.047×VEGFA-0×HIF-1α×VEGFA,所有预测变量可解释因变量的74.7%的方差,VEGFA低表达时,HIF-1α表达与痛阈值的关系较强,当VEGFA高表达时,HIF-1α与痛阈值的关系减弱,直线趋于平缓。结论血清HIF-1α、VEGFA水平与LDHS患者痛阈值关系密切,在对痛阈值影响中具有交互作用。Objective To investigate the relationship and interaction between the levels of hypoxia-inducible factor-1α(HIF-1α)and vascular endothelial growth factor A(VEGFA)in serum and pain threshold in patients with lumbar disc herniation with sciatica(LDHS).Methods A total of 126 LDHS patients in the hospital from May 2020 to February 2023 were selected as case group,and 126 healthy subjects were selected as control group.Serum HIF-1α,VEGFA and pain threshold were compared between the 2 groups.Pearson correlation coefficient was used to analyze the relationship between serum HIF-1αand VEGFA levels and pain threshold.The relationship and interaction between serum HIF-1αand VEGFA level and pain threshold of LDHS patients were analyzed by multiple linear regression.Results The levels of serum HIF-1αand VEGFA in the case group were higher than those in the control group,and the pain threshold was lower than that in the control group(P<0.05).The levels of serum HIF-1α(r=0.777,P<0.001)and VEGFA(r=0.822,P<0.001)in the case group were moderately positive correlated with pain threshold.The levels of serum HIF-1α(r=0.383,P<0.001)and VEGFA(r=0.453,P<0.001)in the control group were not significantly correlated with the pain threshold.Regardless of interaction,there was a linear correlation between serum HIF-1αand VEGFA levels and pain threshold(P<0.05).The fitting equation was Y=-0.409+0.004×HIF-1α+0.019×VEGFA.All the predictors could explain 74.3%of the variance of dependent variable.Considering the interaction,the fitting equation for the pain threshold was Y=19.276+0.062×HIF-1α+0.047×Vegfa-0×HIF-1α×VEGFA,and all the predictors could explain 74.7%of the variance of the dependent variable.When VEGFA expression was low,the relationship between serum HIF-1αexpression and pain threshold was strong.When VEGFA expression was high,the relationship between serum HIF-1αexpression and pain threshold was weak,and the straight line tends to be flat.Conclusion The levels of serum HIF-1αand VEGFA are closely related to the

关 键 词：缺氧诱导因子-1α(HIF-1α) 血管内皮生长因子A(VEGFA) 腰椎间盘突出 坐骨神经痛 交互作用 

分 类 号：R681[医药卫生—骨科学]