Acute Toxicity of Jinchuan Formula Plum Wine Extract and Its Protective Effect on Mice with Liver Injury  

作　　者：Hairong ZHONG Yun TENG Limin LI Yuan LIU 

机构地区：[1]College of Pharmacy,Sichuan College of Traditional Chinese Medicine,Mianyang 621000,China [2]Chengdu Brilliant Pharmaceuticals Co.,Ltd.,Chengdu 610095,China [3]Sichuan Academy of Chinese Medicine Sciences,Chengdu 610041,China [4]Ethnic Medicine Institute,Southwest Minzu University,Chengdu 610041,China

出　　处：《Medicinal Plant》2024年第2期30-32,37,共4页药用植物：英文版

摘　　要：[Objectives]To investigate the acute toxicity and hepatoprotective effect of Jinchuan formula plum wine extract on mice,determine its safety range,and evaluate its hepatoprotective effect.[Methods]The median lethal dose(LD_(50))was determined by acute toxicity test with the toxic reaction and mortality of mice as indexes.Sixty Kunming mice were randomly divided into 6 groups:normal control group,model group(ConA-induced liver injury model),Jinchuan formula plum wine high,medium and low dose groups(1.0,0.5,0.25 g/kg)and silybin group(0.1 g/kg).The levels of ALT,AST,LDH in serum and TG,VLDL in liver were measured.After HE staining,the pathological changes of liver tissue in mice were observed,and the liver protective effect of Jinchuan formula plum wine extract was analyzed and evaluated.[Results]LD_(50)was 11.18 g/kg,and the 95%confidence limit of LD_(50)was 10.31-12.05 g/kg.The high-dose group of Jinchuan formula plum wine extract could significantly reduce the serum ALT and AST activities of ConA-induced liver injury mice(P<0.05).[Conclusions]Jinchuan formula plum wine extract is relatively safe,and also has a protective effect on liver injury.

关 键 词：Jinchuan formula plum wine extract Acute toxicity test ConA-induced liver injury Liver protective effect 

分 类 号：R285.5[医药卫生—中药学]