活血益心方联合穴位贴敷治疗气滞血瘀型慢性心力衰竭临床研究  

Clinical Study on Huoxue Yixin Prescription Combined with Point Application for Chronic Heart Failure of Qi Stagnation and Blood Stasis Type

作　　者：杨红蕾 韩冰 曹艳艳[1] 丁艳丽 闫奎坡[1] 刘艳萍 YANG Hongei;HAN Bing;CAO Yanyan;DING Yanli;YAN Kuipo;LIU Yanping(Heart Center of the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan 450000,China)

机构地区：[1]河南中医药大学第一附属医院心脏中心,河南郑州450000

出　　处：《新中医》2024年第6期52-56,共5页New Chinese Medicine

基　　金：河南省卫生健康委国家中医临床研究基地科研项目(2021JDZX2006,2021JDZX2092);2020-2021年度河南省中医药科学研究专项课题(20-21ZY2029)。

摘　　要：目的:观察活血益心方联合穴位贴敷治疗气滞血瘀型慢性心力衰竭(CHF)的疗效。方法:选择94例气滞血瘀型CHF患者,随机分为联合组和对照组各47例。对照组接受常规西医治疗,联合组在常规西医治疗基础上给予活血益心方联合穴位贴敷治疗。连续治疗4周后,比较2组临床疗效及不良反应发生率,以及治疗前后中医证候评分、心功能指标[左心室射血分数(LVEF)、左心室收缩末期内径(LVESd)、左心室舒张末期内径(LVEDd)]、Lee氏心衰评分、6 min步行距离试验(6MWT)、明尼苏达心衰生活质量量表(MLHFQ)评分。结果:联合组总有效率为95.75%,对照组为82.98%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候主、次症评分均较治疗前降低(P<0.05),且联合组主、次症评分均低于对照组(P<0.05)。治疗后,2组Lee氏心衰评分均较治疗前降低(P<0.05),且联合组评分低于对照组(P<0.05);2组6MWT较治疗前延长(P<0.05),且联合组6MWT大于对照组(P<0.05)。治疗后,2组LVEF较治疗前升高(P<0.05),LVESd、LVEDd均较治疗前缩短(P<0.05);且联合组LVEF高于对照组(P<0.05),LVESd、LVEDd短于对照组(P<0.05)。治疗后,2组MLHFQ评分较治疗前降低(P<0.05),且联合组MLHFQ评分低于对照组(P<0.05)。治疗期间,联合组不良反应发生率为8.51%,对照组为6.38%,2组比较,差异无统计学意义(P>0.05)。结论:活血益心方联合穴位贴敷治疗气滞血瘀型CHF疗效显著,可进一步减轻临床症状,改善患者心功能和生活质量,且安全性良好。Objective:To observe the curative effect of Huoxue Yixin Prescription combined with point application on chronic heart failure(CHF)of qi stagnation and blood stasis type.Methods:A total of 94 cases of CHF patients of qi stagnation and blood stasis type were selected and randomly divided into the combination group and the control group,with 47 cases in each group.The control group was treated with routine western medicine,and the combination group was additionally treated with Huoxue Yixin Prescription combined with point application based on routine western medicine treatment.After 4 weeks of continuous treatment,the clinical effects and incidence of adverse reactions were compared between the two groups.The traditional Chinese medicine(TCM)syndrome scores,heart function indexes[left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESd),and left ventricular end diastolic diameter(LVEDd)],Cardiac Risk Index(Lee Criteria)scores,6-minute Walk test(6MWT),andMinnesota Living with Heart Failure Questionnaire(MLHFQ)scores were compared before and after treatment.Results:The total effective rate was 95.75%in the combination group,higher than that of 82.98%in the control group,the difference being significant(P<0.05).After treatment,the main and secondary symptom scores of TCM syndromes in the two groups were decreased when compared with those before treatment(P<0.05),and the main and secondary symptom scores in the combination group were lower than those in the control group(P<0.05).After treatment,the Lee Criteria scores in the two groups were decreased when compared with those before treatment(P<0.05),and Lee Criteria score in the combination group was lower than that in the control group(P<0.05).The 6MWT was prolonged when compared with that before treatment(P<0.05),and 6MWT in the combination group was longer than that in the control group(P<0.05).After treatment,the LVEF levels in the two groups were increased when compared with those before treatment(P<0.05),and LVESd and LVEDd were shor

关 键 词：慢性心力衰竭 气滞血瘀 活血益心方 穴位贴敷 心功能 生活质量 

分 类 号：R541.6[医药卫生—心血管疾病]