调节性B细胞在自身免疫性皮肤病中的研究进展  

Research progress of regulatory B cells in autoimmune skin diseases

作　　者：董霞[1] DONG Xia(Department of Dermatology and Venereology,Tianjin Public Security Hospital,Tianjin 300041,China)

机构地区：[1]天津市公安医院皮肤性病科,天津300042

出　　处：《中国城乡企业卫生》2024年第3期22-24,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：自身免疫性疾病是机体对自身抗原发生免疫反应所引发的组织损伤疾病,比如系统性红斑狼疮、系统性硬化症以及银屑病等均为常见的自身免疫性疾病。目前学术界对于自身免疫性疾病的发病机制尚未形成明确认识。调节性B细胞是具有抑制功能并且可以参与负向免疫调节的B淋巴细胞,近些年有学者研究显示其在自身免疫性皮肤病发病中具有重要作用。调节性B细胞含量以及功能的变化与多种自身免疫性疾病的发病过程存在密切关系,其所具有的免疫调节功能体现了其在自身免疫性疾病研究中的重要价值。因此近些年很多学者关于调节性B细胞与自身免疫性皮肤病开展了大量的研究工作,并且取得了一些新的认识。基于此,本文对调节性B细胞及其在自身免疫性皮肤病发病中的作用机制的研究进展进行综述,以期为临床自身免疫性皮肤病治疗提供借鉴。Autoimmune diseases are tissue damage diseases caused by the body's immune response to autoantigens,such as systemic lupus erythematosus,systemic sclerosis and psoriasisarecommon autoimmune diseases.At present,the academic community has not formed a clear understanding of the pathogenesis of autoimmune diseases.Regulatory B cells are B lymphocytes with inhibitory function and can participate in negative immune regulation.In recent years,the research by some scholars have shown that it plays an important role in the pathogenesis of autoimmune skin diseases.The changes of the content and function of regulatory B cells are closely related to the pathogenesis of a variety of autoimmune diseases,and its immune regulatory function reflects its important value in the study of autoimmune diseases.Therefore,in recent years,many scholars have carried out a lot of research work on regulatory B cells and autoimmune skin diseases,and achieved some new understanding.Based on this,this paper reviews the research progress of the regulatory B cells and the mechanism of regulatory B cells in the pathogenesis of autoimmune skin diseases,aims to provide reference for clinical treatment of autoimmune skin diseases.

关 键 词：调节性B细胞 自身免疫性皮肤病 研究进展 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]