智能递送系统在基因药物治疗中的应用  

Application of intelligent delivery system in gene drug therapy

作　　者：黄燕妮 王艳 王晓波[3] 李镇[2] 郝堂娜[1] 周雪莹[1] HUANG Yanni;WANG Yan;WANG Xiaobo;LI Zhen;HAO Tangna;ZHOU Xueying(Department of Pharmacy,The Second Hospital of Dalian Medical University,Dalian 116000,China;School of Pharmacy,Dalian Medical University,Dalian 116000,China;The 967th Hospital of Chinese Peoples′Liberation Army Joint Logistics Support Force,Dalian 116000,China)

机构地区：[1]大连医科大学附属第二医院药学部,辽宁大连116000 [2]大连医科大学药学院,辽宁大连116000 [3]中国人民解放军联勤保障部队第967医院,辽宁大连116000

出　　处：《沈阳药科大学学报》2024年第4期482-492,共11页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(81703432)。

摘　　要：随着医药技术的发展,联合递送药物与基因是目前治疗癌症的热门手段,智能递送系统优化了基因药物递送中的载体脱靶性、细胞毒性以及基因药物靶向性等问题。本文通过查阅文献资料,以基因药物、智能递送系统、温度敏感、光敏感、pH敏感、磁性敏感和氧化还原敏感等为关键词,结合查询的相关文献,对基因药物的智能递送进行各方面的介绍并综述了智能递送系统在基因药物治疗中的应用情况。通过智能基因药物递送系统的研发,实现了基因药物在体内对肿瘤微环境产生敏感性应答,从而能够定时、定量、定位智能调控基因药物的释放,为肿瘤基因药物治疗手段的开发提供了更多的策略。With the development of medical technology,the co-delivery of drugs and genes has become a popular approach in cancer treatment.Intelligent delivery systems have solved some issues such as carrier off-targeting,cytotoxicity,and the targeting of gene drugs in gene drug delivery.This article reviews the literature on various aspects of intelligent gene drug delivery using keywords such as“gene drugs”,“intelligent delivery systems”,“temperature-sensitive”,“light-sensitive”,“pH-sensitive”,“magnetic sensitive”,and“redox-sensitive”,and summarizes the applications of intelligent delivery systems in gene drug therapy.Through the development of intelligent gene drug delivery systems,it has been possible to achieve a sensitive response to the tumor microenvironment in the body,thereby enabling the timed,quantitative,and targeted intelligent regulation of gene drug release.The delivery systems could provide more strategies for the development of tumor gene drug therapy modalities.

关 键 词：基因药物 智能递送系统 温度敏感 光敏感 PH敏感 磁性敏感 氧化还原敏感 

分 类 号：R94[医药卫生—药剂学]