自组装颗粒化新冠疫苗研究进展  

Research Advances on COVID-19 Self-Assembled Nanoparticle Vaccine

作　　者：汪晨 尹一凡 林敏 赵小蒙 郑子峥[1] 夏宁邵[1] 张军[1] WANG Chen;YIN Yifan;LIN Min;ZHAO Xiaomeng;ZHENG Zizheng;XIA Ningshao;ZHANG Jun(National Institute of Diagnostics and Vaccine Development in Infectious Diseases,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Schoolof Public Health,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学国家传染病诊断试剂与疫苗工程技术研究中心,厦门大学分子疫苗学和分子诊断学国家重点实验室,厦门大学公共卫生学院,厦门361102

出　　处：《病毒学报》2024年第2期424-431,共8页Chinese Journal of Virology

基　　金：中央高校基本科研业务费专项资金资助(项目号:20720220006),题目:全链条快速疫苗与分子诊断应急响应技术体系建设-夏宁邵-“中央高校基本科研业务费专项资金资助”。

摘　　要：自组装纳米颗粒作为抗原展示平台可以有效增强抗原的免疫效果和稳定性,是有前景的疫苗技术。新冠疫情加速了颗粒化新冠疫苗的发展,目前已有一些应用纳米颗粒的新冠疫苗处于不同的临床试验阶段。本文介绍了几种自组装颗粒化抗原展示平台在新冠疫苗中的应用,并对其免疫机制和研究进展进行了综述。Self-assembled nanoparticles as an antigen display platform can effectively enhance the immune effect and stability of antigens,which is a promising vaccine technology.Covid-19 epidemic has accelerated the development of particulate COVID-19 vaccines,and there are already some COVID-19 vaccines using nanoparticles in various stages of clinical trials.In this paper,the application of several self-assembled particulate antigen display platforms in the COVID-19 vaccine development is introduced,and the immune mechanisms and research progresses are reviewed.

关 键 词：新冠病毒 颗粒化抗原展示平台 自组装 疫苗免疫 

分 类 号：R392[医药卫生—免疫学]