犬腺病毒基因组结构和功能的研究进展  

Research Progress on the Genomic Structure and Function of Canine Adenovirus

作　　者：刘禹含 谢军 孟春春[3] 刘光清[3] 巴音查汗·盖力克 李传峰[3] LIU Yuhan;XIE Jun;MENG Chunchun;LIU Guangqing;Bayinchahan·Gailike;LI Chuanfeng(College of Veterinary Medicine,Xinjiang Agricultural University,Urumqi 830052,China;Jiangsu Agri-Animal Husbandry Vocational College,Taizhou 225300,China;Shanghai Veterinary Research Institute,CAAS,Shanghai 200241,China)

机构地区：[1]新疆农业大学动物医学院,乌鲁木齐830052 [2]江苏农牧科技职业学院,泰州225300 [3]中国农业科学院上海兽医研究所,上海200241

出　　处：《病毒学报》2024年第2期438-446,共9页Chinese Journal of Virology

摘　　要：犬腺病毒病是由犬腺病毒(Canine adenovirus, CAV)所引起的病毒性传染病,该病对犬类繁殖业有较强的危害性。CAV分为两个血清型,CAV-1和CAV-2。两种血清型病毒的形态结构和基因组组成高度相似、抗原性紧密相关,然而两种血清型病毒感染犬后产生的疾病表型、组织细胞嗜性和血凝特性等方面存在明显的差异。本文拟从两种血清型病毒的基因组结构及其编码蛋白功能上进行比较分析,以期为两种血清型CAV的生物学特性和致病性差异的研究以及鉴别诊断技术的建立提供参考。Canine adenovirus disease(CAD)is a viral infectious disease caused by canine adenovirus(CAV)CAD is highly harmful to the dog-breeding industry.The CAV is divided into two serotypes:CAV-1 and CAV-2.The morphological structure and genome composition of these two virus types are highly similar,and antigenicity is closely related.However,there are obvious differences in disease phenotype,histiocytes and hemagglutination characteristics produced by these two virus types in dogs.We compared and analyzed the genome structure and function of the proteins that CAV1 and CAV2 encode.In this way,we provided a reference for study of the biological characteristics and pathogenicity differences of CAV-1 and CAV-2,and establishment of differential diagnostic methods.

关 键 词：犬腺病毒 形态结构 基因组结构 蛋白功能 

分 类 号：S855.3[农业科学—临床兽医学]