心外膜脂肪与青年人冠状动脉管腔狭窄的相关性研究  

Correlation study between epicardial fat and coronary artery lumen stenosis in young adults

作　　者：张艳春[1] 谢丽响 王浩[1] 梁永[1] 董坤 刘欢 ZHANG Yanchun;XIE Lixiang;WANG Hao;LIANG Yong;DONG Kun;LIU Huan(Department of Imaging,Suining County People's Hospital,Xuzhou,Jiangsu Province 221200,China;Department of Imaging,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu Province 221002.China)

机构地区：[1]睢宁县人民医院影像科,江苏徐州221200 [2]徐州医科大学附属医院影像科,江苏徐州221002

出　　处：《实用放射学杂志》2024年第3期373-376,393,共5页Journal of Practical Radiology

摘　　要：目的探讨心外膜脂肪体积(EFV)、心外膜脂肪体积指数(EFVi)与青年人冠状动脉管腔狭窄的相关性.方法回顾性分析2周内同时行冠状动脉CT血管成像(CCTA)、冠状动脉造影(CAG)检查的80例青年患者资料,评估EFV、EFVi与青年人冠状动脉管腔狭窄的相关性.结果80例患者,以CAG检查结果为评判冠状动脉管腔狭窄的金标准,病变组58例,对照组22例;青年人冠状动脉管腔狭窄男性发病率高于女性(t=4.309,P=0.038).病变组EFV、EFVi均高于对照组(t=3.023,P=0.001;t=2.785,P=0.001).男性EFV高于女性(t=2.558,P=0.012),男、女2组EFVi差异无统计学意义.男性病变组和对照组EFV、EFVi差异均有统计学意义(t=4.083,P<0.01;t=4.429,P<0.01),女性病变组和对照组EFV、EFVi差异均无统计学意义.EFV、EFVi与冠状动脉管腔狭窄均呈中度正相关(rs=0.437,P<0.01;rs=0.463,P<0.01).对EFV和EFVi进行受试者工作特征(ROC)曲线分析,EFV的曲线下面积(AUC)0.784,临界值107.24 cm3,敏感度0.776,特异度0.682;EFVi的AUC 0.793,临界值53.68 cm3/m2,敏感度0.81,特异度0.682.结论EFV、EFVi与青年人冠状动脉管腔狭窄呈中度正相关,对冠心病的诊断有一定帮助,但青年女性病变组和对照组EFV、EFVi差异无统计学意义.Objective To explore the correlation between epicardial fat volume(EFV),epicardial fat volume indexed(EFVi)and coronary artery lumen stenosis in young adults.Methods The data of 80 young patients who underwent both coronary computed tomography angiography(CCTA)and coronary angiography(CAG)within 2 weeks were analyzed retrospectively.The correlation between EFV,EFVi and coronary artery lumen stenosis in young adults was evaluated.Results A total of 80 patients were enrolled,taking CAG exomination results as the gold standard,58 cases were enrolled into the lesion group and the other 22 cases were enrolled into the control group.The incidence of coronary artery lumen stenosis was higher in young males than that in young females(t=4.309,P=0.038).EFV and EFVi in the lesion group were higher than those in the control group(t=3.023,P=0.001;t=2.785,P=0.001).The EFV in males was higher than that in females(t=2.558,P=0.012).There was no significant difference in EFVi between male and female groups.The differences between EFV and EFVi of males in lesion group and control group were statistically significant(t=4.083,P<0.01;t=4.429,P<0.01).The differences between EFV and EFVi of females in lesion group and control group showed no sta-tistical significance.EFV and EFVi were moderately positively correlated with coronary artery lumen stenosis(rs=0.437,P<0.01;rs=0.463,P<0.01).Receiver operating characteristic(ROC)curve analysis of EFV and EFVi showed that the area under the curve(AUC)of EFV was 0.784,the cut-off value was 107.24 cm3,the sensitivity was 0.776,and the specificity was 0.682.The AUC,cut-off value,sensitivity and specificity of EFVi was 0.793,53.68 cm3/m2,0.81,0.682,respectively.Conclusion EFV and EFVi are moderately positively correlated with coronary artery lumen stenosis in young adults,which is helpful to the diagnosis of coronary heart disease.However,the differences between EFV and EFVi of young females in lesion group and control group show no statistical significance.

关 键 词：心外膜 冠状动脉狭窄 冠状动脉造影 计算机体层成像 

分 类 号：R543.3[医药卫生—心血管疾病] R814.43[医药卫生—内科学] R814.42[医药卫生—临床医学]