氟比洛芬酯对根治性胃切除患者围手术期体温及寒颤的影响  

Effect of flurbiprofen axetil on perioperative body temperature andshivering in patients undergoing radical gastrectomy

作　　者：王杰 刘辉[1] 汪志勇 张民皓[1] 鲁振[1] 谢辉兰[1] WANG Jie;LIU Hui;WANG Zhiyong;ZHANG Minghao;LU Zhen;XIE Huilan(Department of Anesthesiology,Jiangsu Provincial Tumor Hospital/Jiangsu Provincial Research Institute of Tumor Prevention and Treatment/Affiliated Tumor Hospital of Nanjing Medical University,Nanjing,Jiangsu 210009,China)

机构地区：[1]江苏省肿瘤医院/江苏省肿瘤防治研究所/南京医科大学附属肿瘤医院麻醉科,南京210009

出　　处：《重庆医学》2024年第8期1194-1197,共4页Chongqing medicine

基　　金：江苏省卫生健康委课题(Z2019023);江苏省麻醉重点实验室开放课题(XZSYSKF2019024)。

摘　　要：目的探讨氟比洛芬酯对行根治性胃切除术的患者围手术期体温及寒颤发生的影响。方法选取2022年1-8月择期行根治性胃切除术并术后进入苏醒室的120例患者作为研究对象,美国麻醉医师协会(ASA)分级Ⅱ~Ⅲ级。采用随机数字表法将患者分为氟比洛芬酯组(F组)和对照组(C组),每组60例。F组在麻醉诱导后静脉输注氟比洛芬酯100 mg(10 mL),C组在麻醉诱导后静脉输注10 mL生理盐水。收集患者一般资料,记录患者手术前(T_(0))、入恢复室(T_(1))、出恢复室(T_(2))时的血压、心率、平均动脉压及耳膜温度,评估入恢复室后出现的寒颤次数、强度分级及持续时间。记录两组患者拔管后10 min(T_(3))、30 min(T_(4))VAS评分及恶心、呕吐等不良反应。结果与T_(0)相比,T_(1)、T_(2)时间点两组患者耳膜温度明显降低(P<0.05),T_(1)、T_(2)时间点两组耳膜温度无明显差异(P>0.05),入恢复室期间F组患者较C组患者寒颤发生率明显降低且强度较轻(P<0.05),但寒颤发生持续时间差异无统计学意义(P>0.05)。F组T_(3)、T_(4)时间点VAS评分明显低于C组(P<0.05),两组术后恶心呕吐发生率差异无统计学意义(P>0.05)。结论氟比洛芬酯可以改善根治性胃切除术患者术后疼痛及寒颤的发生,但并不影响围手术期低体温的发生。Objective To investigate the effect of flurbiprofen axetil on perioperative body temperature and shivering in the patients undergoing radical gastrectomy.Methods A total of 120 patients with ASA gradeⅡorⅢwho underwent radical gastrectomy and entered the recovery room after operation from January to August 2022 were selected.The patients were divided into the flurbiprofen axetil group(F group)and control group(C group)by the random number table method,60 cases in each group.The group F was intravenously infused by flurbiprofen axetil 100 mg(10 mL)after anesthesia induction,and the group C was intravenously infused after anesthesia induction.The general data of the patients were collected.The blood pressure,heart rate,mean arterial pressure and eardrum temperature of the patients were records before operation(T_(0)),entering the recovery room(T_(1))and leaving the recovery room(T_(2)).The number,intensity grade and duration of chills after entering the recovery room were evaluated.The VAS scores and adverse reactions such as nausea and vomiting were recorded at 10 min(T_(3))and 30 min(T_(4))after extubation.Results Compared with at T_(0),the eardrum temperature of the two groups at T_(1) and T_(2) was significantly decreased(P<0.05).There was no significant difference in ear temperature at T_(1) and T_(2) between the two groups(P>0.05).Compared with the control group,the incidence of shivering was significantly improved and the intensity was lighter in the F group(P<0.05).However,there was no statistically significant difference in the duration of shivering(P>0.05).The VAS scores at T_(3) and T_(4) in the group F were significantly lower than those in the group C(P<0.05).There was no statistically significant difference in the incidence rate of postoperative nausea and vomiting between the two groups(P>0.05).Conclusion Flurbiprofen axetil could improve the occurrence of postoperative pain and shivering in the patients with radical gastrectomy,but does not affect the occurrence of perioperative hypothermia.

关 键 词：氟比洛芬酯 低体温 寒颤 围手术期 

分 类 号：R656.61[医药卫生—外科学]