增强T2 FLAIR序列在颅内肿瘤影像诊断中的研究进展  

Research progress of contrast-enhanced T2 FLAIR in intracranial neoplasms imaging diagnosis

作　　者：梁泓中 郭睿[2,3] 肖运平 LIANG Hongzhong;GUO Rui;XIAO Yunping(Graduate School of Guangxi University of Chinese Medicine,Nanning 530200,China;Department of Radiology,Liuzhou People's Hospital Affiliated to Guangxi Medical University,Liuzhou 545006,China;Liuzhou Key Laboratory of Molecular Imaging,Liuzhou 545006,China;Guangxi Key Laboratory of Clinical Disease Biotechnology,Liuzhou 545006,China)

机构地区：[1]广西中医药大学研究生院,南宁530200 [2]广西医科大学附属柳州市人民医院放射科,柳州545006 [3]柳州市分子影像重点实验室,柳州545006 [4]广西临床疾病生物技术研究重点实验室,柳州545006

出　　处：《磁共振成像》2024年第4期207-213,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：柳州市科技计划项目(编号:2022CAC0208);广西壮族自治区卫生健康委员会自筹经费课题(编号:Z-B20221364)。

摘　　要：在颅内肿瘤诊疗过程中,对比增强MRI扫描是常用的影像学评估手段。临床上颅脑MRI增强检查首选T1WI序列。长期以来,增强T2液体衰减反转恢复(fluid-attenuated inversion recovery,FLAIR)被认为是评估软脑膜疾病和脑转移瘤的辅助序列。近年来,不断有研究报道增强T2 FLAIR序列在血脑屏障、血软脑膜屏障、血脑脊液屏障、血眼屏障、血迷路屏障及淋巴系统损伤相关疾病的检出、鉴别诊断方面具有一定优势。增强T2 FLAIR序列尽管在颅内肿瘤影像诊断中展现出巨大的潜力,但目前尚未广泛应用于临床,原因包括:(1)增强T2 FLAIR适用的疾病谱尚未完全阐明,(2)增强T2 FLAIR的规范扫描参数尚未确定,(3)增加MRI检查时间等。本文针对增强T2 FLAIR序列的技术特点、正常影像表现以及在颅内肿瘤影像诊断中的应用现状、最新进展进行综述,为以后进一步科研、临床应用提供参考。Contrast-enhanced MRI is a radiological assessment tool commonly used in the diagnosis and treatment of intracranial neoplasms.T1WI sequence is clinically the first choice for contrast-enhanced brain MRI.For a long time,contrast-enhanced T2 fluid-attenuated inversion recovery(FLAIR)has been considered as an auxiliary sequence for assessing leptomeningeal diseases and brain metastases.In recent years,studies have continuously reported that contrast-enhanced T2 FLAIR has certain advantages in the detection and differential diagnosis of diseases related to blood-brain barrier,blood-leptomeningeal barrier,blood-cerebrospinal fluid barrier,blood-ocular barrier,blood-labyrinthine barrier and lymphatic system injuries.Although contrast-enhanced T2 FLAIR has demonstrated the tremendous potential in the imaging diagnosis of intracranial neoplasms,contrast-enhanced T2 FLAIR has not been widely used in clinical practice due to the reasons such as:(1)the spectrum of diseases suitable for contrast-enhanced T2 FLAIR has not been fully elucidated,(2)the standard scanning parameters for contrast-enhanced T2 FLAIR have not been determined,(3)it increases the MRI examination time.This article provides an overview of the technical characteristics,normal imaging manifestations,current application status,and latest progress of the contrast-enhanced T2 FLAIR sequence in intracranial neoplasms imaging diagnosis.Provide references for further scientific research and clinical applications in the future.

关 键 词：颅内肿瘤 磁共振成像 对比剂 液体衰减反转恢复 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]