金刚藤胶囊联合抗菌药物治疗慢性盆腔炎的有效性和安全性的Meta分析  

Efficacy and Safety of Jingangteng Capsules Combined with Antimicrobial Drugs in the Treatment of Chronic Pelvic Inflammatory Disease:A Meta-analysis

作　　者：刘幸 李畏娴 武彦 吴雪娇 姚晓蝶 陈洁 沈凌筠 樊浩 LIU Xing;LI Weixian;WU Yan;WU Xuejiao;YAO Xiaodie;CHEN Jie;SHEN Lingjun;FAN Hao(Yunnan Clinical Center for Infectious Diseases/Dept.of Pharmacy,The 3rd People’s Hospital of Kunming,Kunming Yunnan 650041;School of Pharmaceutical Sciences,Dali University,Dali Yunnan 671000,China)

机构地区：[1]云南省传染病临床医学中心/昆明市第三人民医院药学部,云南昆明650041 [2]大理大学药学院,云南大理671000

出　　处：《昆明医科大学学报》2024年第4期81-91,共11页Journal of Kunming Medical University

基　　金：云南省教育厅科学研究基金资助项目(2024J0879);昆明市卫健委科研基金资助项目(2022-03-08-004)。

摘　　要：目的系统评价金刚藤胶囊联合抗菌药物治疗慢性盆腔炎的有效性和安全性。方法检索国内外数据库中金刚藤胶囊联合抗菌药物治疗慢性盆腔炎的随机对照试验(RCTs)研究,使用RevMan 5.4软件进行Meta分析。结果最终纳入24篇RCTs研究,样本量共计2441例。Meta分析结果显示,金刚藤胶囊联用抗菌药物可显著提高慢性盆腔炎患者的临床总有效率[RR=1.19,95%CI(1.15,1.23),P<0.001];与单纯使用抗菌药物治疗相比还能降低不良事件的发生率[RR=0.70,95%CI(0.51,0.95),P<0.05]。此外,金刚藤胶囊联合抗菌药物治疗慢性盆腔炎与单纯抗菌药物治疗相比在促进炎性因子、淋巴细胞恢复上均有明显改善(P<0.05),可缩短症状缓解时间和改善血液流变学指标(P<0.05)。结论金刚藤胶囊联合抗菌药物治疗慢性盆腔炎有较好的疗效和安全性,但鉴于研究证据质量情况,需结合临床实践综合应用。Objective To systematically evaluate the efficacy and safety of Jingangteng capsule combined with antibiotics in the treatment of chronic pelvic inflammatory disease.Methods Randomized controlled trials(RCTs)of Jingangteng capsule combined with antibiotics in the treatment of chronic pelvic inflammatory disease were searched from domestic and foreign databases.RevMan 5.4 software was used for Meta-analysis.Results Twenty-four studies of RCTs were finally included,with a total sample size of 2,441 cases.Meta-analysis showed that the combination of antimicrobial drugs with Jingangteng capsule significantly increased the overall clinical effectiveness rate of patients with chronic pelvic inflammatory disease[RR=1.19,95%CI(1.15,1.23),P<0.001].It also reduced the incidence of adverse events compared with treatment with antimicrobial drugs alone[RR=0.70,95%CI(0.51,0.95),P<0.05].In addition,the treatment of chronic pelvic inflammatory disease with Jingangteng capsule combined with antimicrobial drugs improved in promoting the recovery of inflammatory factor,and lymphocytes compared with antimicrobial drug therapy alone(P<0.05),and also effectively shortened the symptomatic remission time and improved the hemorheological indexes(P<0.05).Conclusion Jingangteng capsule combined with antibacterial agents has good efficacy and safety in the treatment of chronic pelvic inflammatory disease,but in view of the quality of research evidence,it should be applied according to the actual clinical situation.

关 键 词：金刚藤胶囊 慢性盆腔炎 系统评价 META分析 

分 类 号：R71[医药卫生—妇产科学]