血栓弹力图及凝血指标在妊娠期高血压疾病中的临床研究  

Clinical study of thromboelastogram and coagulation indexes in hypertensive diseases in pregnancy

作　　者：张雨婷 陈秋连 涂韵之 Zhang Yu-ting;Chen Qiu-lian;Tu Yun-zhi(Department of Obstetrics,Xinyu People's Hospital,Xinyu 338000,Jiangxi,China)

机构地区：[1]新余市人民医院产科,江西新余338000

出　　处：《四川生理科学杂志》2024年第4期733-735,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨血栓弹力图(Thromboelastogram,TEG)及凝血指标在妊娠期高血压疾病(Hypertensive disorders in pregnancy,HDP)中的临床应用。方法:选取2022年1月至2023年6月我院收治的HDP孕妇60例为研究对象,根据疾病情况分为高血压(Gestational hypertension,GH)组28例、子痫前期(Preeclampsia,PE)组20例、重度子痫前期(Severe preeclampsia,SPE)组12例,选取无妊娠合并症孕妇40例作为对照组,比较四组TEG及凝血指标,分析两种检测指标相关性及高凝状态阳性率。结果:凝血酶原时间(Prothrombin time,PT)、凝血酶时间(Thrombin time,TT)、活化部分凝血活酶时间(Activated partial thromboplastin time,APTT)、凝血反应时间(Reaction time,R)、凝血形成时间(Kinetic time,K)从长到短依次为对照组、GH组、PE组、SPE组,纤维蛋白原(Fibrinogen,FIB)、凝固角(Angle,α)、血栓最大振幅(Maximum amplitude,MA)从大到小依次为SPE组、PE组、GH组、对照组(P<0.05)。R、K与PT、TT、APTT呈正相关,与FIB呈负相关;α与FIB呈正相关,与TT、APTT呈负相关;MA与FIB呈正相关,与APTT呈负相关(P<0.05)。TEG阳性检出率高于凝血指标(P<0.05)。结论:与凝血指标相比,TEG能更准确反映HDP孕妇凝血状态。Objective:To investigate the clinical application of thromboelastogram(TEG)and coagulation indexes in hypertensive disorders in pregnancy(HDP).Method:A total of 60 HDP pregnant women admitted to our hospital from January 2022 to June 2023 were selected as the study objects.The patients were divided into Gestational hypertension(GH)group(28 cases),preeclampsia(PE)group(20 cases)and severe preeclampsia(SPE)group(12 cases).Forty pregnant women without pregnancy complications were selected as the control group.TEG and coagulation indexes of the four groups were compared,and the correlation between the two indexes and the positive rate of hypercoagulability were analyzed.Result:Prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),reaction time(R)and kinetic time(K)from long to short were control group,GH group,PE group,SPE group.The value of fibrinogen(FIB),coagulation angle(α)and maximum amplitude(MA)of thrombus from large to small were SPE group,PE group,GH group,control group(P<0.05).R and K were positively correlated with PT,TT and APTT,but negatively correlated with FIB.αwas positively correlated with FIB and negatively correlated with TT and APTT.MA was positively correlated with FIB and negatively correlated with APTT(P<0.05).Conclusion:Compared with the coagulation indexes,TEG can more accurately reflect the coagulation status of pregnant women with HDP.

关 键 词：TEG 凝血常规 HDP 凝血状态 

分 类 号：R714.246[医药卫生—妇产科学]