血清Sclerostin、miR-155-5p、FGF-23水平联合检测对尿毒症血液透析患者发生血管钙化的诊断价值  

Diagnostic value of serum Sclerostin,miR-155-5p and FGF-23 combined detection for vascular calcification in hemodialysis patients with uremia

作　　者：许鹏鸽 茹幸蕊 黄海燕 Xu Peng-ge;Ru Xing-rui;Huang Hai-yan(Blood Purification Department of The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan,China)

机构地区：[1]河南科技大学第一附属医院血液净化科,河南洛阳471000

出　　处：《四川生理科学杂志》2024年第4期769-772,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨尿毒症血液透析患者血清骨硬化蛋白(Sclerostin,Sost)、微小RNA-155-5p(microRNA-155-5p,miR-155-5p)、成纤维细胞生长因子-23(Fibroblast growth factor-23,FGF-23)水平,分析其对血管钙化的诊断价值。方法:选取2020年1月~2022年12月本院收治的92例尿毒症血液透析患者作为研究对象,依据是否发生血管钙化分为钙化组(n=68)和非钙化组(n=24)。检测并比较两组生化指标及血清Sost、miR-155-5p、FGF-23水平。分析血清指标与生化指标、钙化程度相关性。采用受试者工作特征曲线(Receiver operating characteristic curve,ROC)分析血清指标对血管钙化的诊断价值。结果:钙化组血清Sost、miR-155-5p、FGF-23水平高于非钙化组(P<0.05);血清Sost、miR-155-5p、FGF-23水平与骨形成蛋白2(Bone morphogenetic protein 2,BMP-2)、全段甲状旁腺激素(Intact parathyroid hormone,iPTH)、钙化程度呈正相关(P<0.05);血清Sost、miR-155-5p、FGF-23联合诊断血管钙化的AUC大于单项指标诊断(P<0.05)。结论:尿毒症血液透析患者中,血管钙化者血清Sost、miR-155-5p、FGF-23水平升高,且与血管钙化程度呈正相关,联合检测其水平对血管钙化具有一定诊断价值。Objective:To investigate the serum levels of Sclerostin(Sost),microRNA-155-5p(miR-155-5p),and Fibroblast growth factor-23(FGF-23)in uremic hemodialysis patients,and to analyze their diagnostic value for vascular calcification.Methods:Ninety-two cases patients with uremic hemodialysis admitted to our hospital from January 2020 to December 2022 were selected as the study subjects.They were divided into a calcification group(n=68)and a non-calcification group(n=24)based on whether vascular calcification occurred.Detect and compare the biochemical indicators and serum levels of So,miR-155-5p,and FGF-23 between the two groups.Analyze the correlation between serum indicators,biochemical indicators,and degree of calcification.Use receiver operating characteristic(ROC)to analyze the diagnostic value of serum indicators for vascular calcification.Results:Serum levels of Sost,miR-155-5p and FGF-23 in calcification group were higher than those in non-calcification group(P<0.05).Serum Sost,miR-155-5p and FGF-23 levels were positively correlated with bone morphogenetic protein 2(BMP-2),whole parathyroid hormone(iPTH)and calcification degree(P<0.05).The AUC of serum Sost,miR-155-5p,FGF-23 combined diagnosis of vascular calcification was higher than that of single index diagnosis(P<0.05).Conclusion:Serum levels of Sost,miR-155-5p and FGF-23 increased in patients with vascular calcification in hemodialysis patients with uremia,and were positively correlated with the degree of vascular calcification.Combined detection of their levels has certain diagnostic value for vascular calcification.

关 键 词：尿毒症 血管钙化 骨硬化蛋白 微小RNA-155-5p 成纤维细胞生长因子-23 

分 类 号：R692.5[医药卫生—泌尿科学]