Disease networks. Uncovering disease-disease relationships through the incomplete interactome  

作　　者：Jörg Menche 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2024年第4期772-772,共1页Sichuan Journal of Physiological Sciences

摘　　要：According to the disease module hypothesis,the cellular components associated with a disease segregate in the same neighborhood of the human interactome,the map of biologically relevant molecular interactions.Yet,given the incompleteness of the interactome and the limited knowledge of disease-associated genes,it is not obvious if the available data have sufficient coverage to map out modules associated with each disease.Here we derive mathematical conditions for the identifiability of disease modules and show that the network-based location of each disease module determines its pathobiological relationship to other diseases.For example,diseases with overlapping network modules show significant coexpression patterns,symptom similarity,and comorbidity,whereas diseases residing in separated network neighborhoods are phenotypically distinct.These tools represent an interactome-based platform to predict molecular commonalities between phenotypically related diseases,even if they do not share primary disease genes.

关 键 词：INCOMPLETE NEIGHBORHOOD network 

分 类 号：R33[医药卫生—人体生理学]