NCPAP,雾化吸入联合IHIG辅助治疗重症肺炎的作用分析  

Effect analysis of NCPAP,nebulization combined with IHIG in the treatment of severe pneumonia

作　　者：许兆颖 魏晓丽 龚文品 Xu Zhao-ying;Wei Xiao-li;Gong Wen-pin(ICU,Nanyang Central Hospital,Nanyang 473000,Henan,China;Out-patient Department,Nanyang Central Hospital,Nanyang 473000,Henan,China;The Second Ward of Gastrointestinal Disease,Nanyang Central Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市中心医院感染ICU,河南南阳473000 [2]南阳市中心医院门诊部,河南南阳473000 [3]南阳市中心医院胃肠二病区,河南南阳473000

出　　处：《四川生理科学杂志》2024年第4期864-866,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨重症肺炎患者应用经鼻高流量正压通气(Nasal high flow positive pressure ventilation,NCPAP)、雾化吸入联合人免疫球蛋白(Human immunoglobulin,IHIG)辅助治疗的效果。方法:选取2021年2月至2023年2月医院收治重症肺炎患者82例,采用随机数字表格法分为对照组和观察组,每组各41例。对照组接受常规治疗,观察组在此基础上使用NCPAP+雾化吸入+IHIG联合治疗。分析对比两组的疗效,治疗前、治疗后5 d以肺功能仪检测肺功能,酶联免疫法检测肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、内皮素(Endothelin-1,ET-1)水平。结果:观察组有效率高于对照组(P<0.05)。干预后,观察组的肺功能水平均显著优于对照组(P<0.05)。干预后观察组的TNF-α、ET-1水平均显著低于对照组(P<0.05)。结论:重症肺炎NCPAP+雾化吸入+IHIG联合可提高疗效,改善肺功能,降低TNF-α与ET-1表达。Objective:To investigate the effect of Nasal high flow positive pressure ventilation(NCPAP),aerosol inhalation combined with Human immunoglobulin(IHIG)in the treatment of patients with severe pneumonia.Methods:A total of 82 patients with severe pneumonia admitted to the hospital from February 2021 to February 2023 were divided into control group and observation group by random number table method,with 41 cases in each group.The control group received conventional treatment,and the observation group received NCPAP+nebulization+IHIG combined treatment on this basis.The therapeutic effects of thetwo groups were analyzed and compared.Lung function was detected by pulmonary function instrument before and 5 days after treatment,and Tumor Necrosis Factor-α(TNF-α)and endothelin-1(ET-1)were detected by enzyme-linked immunotherapy.Results:The effective rate of observation group was higher than that of control group(P<0.05).After intervention,the lung function level of the observation group was significantly better than that of the control group(P<0.05).After intervention,the levels of TNF-αand ET-1 in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:The combination of NCPAP+nebulize inhalation+IHIG can improve the therapeutic effect,improve lung function,and reduce the expression of TNF-αand ET-1 in severe pneumonia.

关 键 词：重症肺炎 鼻高流量正压通气 雾化吸入 人免疫球蛋白 

分 类 号：R563.1[医药卫生—呼吸系统]