一次性根管治疗牙体牙髓病的效果及对血清骨保护素和炎性因子水平的影响探讨  

The effect of one-visit endodontic therapy on dental pulp disease and its influence on serum levels of osteoprotectin and inflammatory factors

作　　者：刘红军 LIU Hong-jun(Department of Stomatology,Yangxin County People's Hospital,Binzhou 251800,China)

机构地区：[1]阳信县人民医院口腔科,251800

出　　处：《中国实用医药》2024年第7期87-90,共4页China Practical Medicine

摘　　要：目的探讨牙体牙髓病患者应用一次性根管治疗的效果及对血清骨保护素(OPG)和炎性因子水平的影响。方法200例牙体牙髓病患者,以随机数字表法分为对照组(100例)和观察组(100例)。对照组应用多次法根管治疗,观察组应用一次性根管治疗。观察对比两组临床效果、并发症发生率及治疗前后的咀嚼功能(咬合力与咀嚼效率)、疼痛程度[视觉模拟评分法(VAS)评分]、OPG、破骨细胞分化因子(RANKL)、血清炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平。结果观察组治疗总有效率96.00%高于对照组的87.00%(P<0.05)。与治疗前相比,两组治疗后咬合力与咀嚼效率均升高,VAS评分均下降,且观察组治疗后咬合力与咀嚼效率高于对照组,VAS评分低于对照组(P<0.05)。与治疗前比较,治疗后两组OPG水平升高,RANKL水平降低,且观察组治疗后OPG水平高于对照组,RANKL水平低于对照组(P<0.05)。与治疗前对比,治疗后两组CRP、TNF-α、IL-6水平均降低,且观察组CRP(4.02±1.07)mg/L、TNF-α(3.07±0.68)ng/L、IL-6(1.03±0.24)ng/L均低于对照组的(7.36±1.68)mg/L、(5.98±0.89)ng/L、(1.79±0.33)ng/L(P<0.05)。观察组并发症发生率4.00%显著低于对照组的16.00%(P<0.05)。结论一次性根管治疗牙体牙髓病的效果确切,能够促进咀嚼功能的改善,减轻疼痛程度,还可调节OPG,减轻炎性因子水平,同时并发症更少,安全性更佳,值得推广。Objective To explore the effect of one-visit endodontic therapy on dental pulp disease and its influence on serum levels of osteoprotectin(OPG)and inflammatory factors.Methods 200 patients with dental pulp disease were divided into a control group(100 cases)and an observation group(100 cases)by random number table method.The control group received multiple-visit endodontic therapy,and the observation group received one-visit endodontic therapy.Observation and comparison were made on clinical effect,complication rate,masticatory function(biting force and masticatory efficiency),pain intensity[visual analogue scale(VAS)score],OPG,osteoclast differentiation factor(RANKL),serum inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)]levels between the two groups.Results The total effective rate of the observation group was 96.00%,which was higher than 87.00%of the control group(P<0.05).Compared with before treatment,both the biting force and masticatory efficiency of the two groups increased after treatment,and the VAS score decreased;and the biting force and masticatory efficiency of the observation group were higher than those of the control group,and VAS score was lower than that of the control group(P<0.05).Compared with before treatment,OPG level increased and RANKL level decreased in the two groups after treatment;and OPG level in the observation group was higher than that in the control group and RANKL level was lower than that in the control group after treatment(P<0.05).Compared with before treatment,the levels of CRP,TNF-αand IL-6 decreased in both groups after treatment;the observation group had CRP of(4.02±1.07)mg/L,TNF-αof(3.07±0.68)ng/L and IL-6 of(1.03±0.24)ng/L,which were lower than(7.36±1.68)mg/L,(5.98±0.89)ng/L and(1.79±0.33)ng/L in the control group(P<0.05).The complication rate of the observation group was 4.00%,which was significantly lower than 16.00%of the control group(P<0.05).Conclusion One-visit endodontic therapy shows definite effect on

关 键 词：牙体牙髓病 一次性根管 多次法根管 咀嚼功能 血清骨保护素 炎性因子 

分 类 号：R781.3[医药卫生—口腔医学]