干扰素联合抗病毒口服液治疗幼儿手足口病的临床疗效观察  

Clinical observation of interferon combined with antiviral oral liquid in the treatment of hand,foot and mouth disease in young children

作　　者：孟庆伟 MENG Qing-wei(Department of Pediatrics,Yongfeng Banger Hospital,Ji'an 331500,China)

机构地区：[1]永丰邦尔医院儿科,331500

出　　处：《中国实用医药》2024年第7期129-131,共3页China Practical Medicine

摘　　要：目的观察干扰素联合抗病毒口服液治疗幼儿手足口病的临床疗效。方法50例手足口病患儿为研究对象,随机分为对照组和研究组,每组25例。两组患儿均行常规手足口病治疗,对照组患儿同时接受干扰素治疗,研究组接受干扰素联合抗病毒口服液治疗。比较两组患儿临床指标恢复时间、治疗前后病原体阳性率、治疗效果、治疗安全性。结果结果显示,研究组体温恢复时间(2.59±0.84)d、疱疹消失时间(3.27±1.08)d、皮疹消失时间(4.87±0.59)d、总治疗时间(5.08±1.38)d均短于对照组的(3.12±0.94)、(4.51±1.27)、(5.29±0.69)、(5.91±1.46)d,差异具有统计学意义(P<0.05)。治疗后,研究组患儿萨奇病毒A16型阳性2例(8%)、肠道病毒阳性3例(12%)、肠道病毒71型阳性1例(4%),对照组患儿萨奇病毒A16型阳性8例(32%)、肠道病毒阳性9例(36%)、肠道病毒71型阳性6例(24%)。与对照组比较,研究组患儿的科萨奇病毒A16型、肠道病毒、肠道病毒71型阳性率显著更低,差异具有统计学意义(P<0.05)。对照组患儿中,治愈12例(48%),有效9例(36%),无效4例(16%);研究组患儿中,治愈18例(72%),有效7例(28%),无效0例。研究组治总有效100%显著高于对照组的84%,差异具有统计学意义(P<0.05)。结论干扰素联合抗病毒口服液治疗手足口病患儿起效时间快,可降低病原体阳性率,安全性较好,临床上值得推广应用。Objective To observe the clinical efficacy of interferon combined with antiviral therapy in the treatment of hand,foot and mouth disease in young children.Methods A total of 50 patients with hand,foot and mouth disease were selected and randomly divided into a research group and a control group,with 25 cases in each group.Both groups of children received conventional treatment.The control group was treated with interferon,and the research group was treated with interferon and antiviral oral liquid.The recovery time of clinical indicators,positive rate of pathogens before and after treatment,therapeutic effect and therapeutic safety were compared between the two groups.Results The results showed that the body temperature recovery time of the research group was(2.59±0.84)d,the herpes disappearance time was(3.27±1.08)d,the rash disappearance time was(4.87±0.59)d,and the total treatment time was(5.08±1.38)d,which were shorter than(3.12±0.94),(4.51±1.27),(5.29±0.69),and(5.91±1.46)d of the control group,and the difference was statistically significant(P<0.05).After treatment,2 cases(8%)in the study group were positive for coxasckievirus A16,3 cases(12%)were positive for enterovirus,and 1 case(4%)was positive for enterovirus 71;8 cases(32%)in the control group were positive for coxasckievirus A16,9 cases(36%)were positive for enterovirus,and 6 cases(24%)was positive for enterovirus 71.Compared with the control group,the positive rates of coxasckievirus A16,enterovirus and enterovirus 71 in the study group were significantly lower,and the difference was statistically significant(P<0.05).In the control group,12 cases(48%)were cured,9 cases(36%)were effective,and 4 cases(16%)were ineffective;in the study group,18 cases(72%)were cured,7 cases(28%)were effective and 0 case was ineffective.The total effective rate of the study group was 100%,which was higher than 84%of the control group,and the difference was statistically significant(P<0.05).Conclusion Interferon combined with antiviral oral liquid in the treatment o

关 键 词：干扰素 抗病毒口服液 手足口病 临床疗效 

分 类 号：R725.1[医药卫生—儿科]