清金化痰汤联合西医常规治疗对慢性阻塞性肺疾病急性加重期患者临床疗效的Meta分析  

Clinical Efficacy of Qingjin Huatan Decoction Combined with Conventional Western Medicine in Patients with AECOPD:a Meta-analysis

作　　者：邢帅 张盼盼 邵旭鹏 迟培枫 张铎 范开亮[1] Xing Shuai;Zhang Panpan;Shao Xupeng;Chi Peifeng;Zhang Duo;Fan Kailiang(The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong,Jinan 250014,China)

机构地区：[1]山东中医药大学附属医院,山东济南250014 [2]山东省济南市章丘区中医医院,山东济南250200 [3]山东中医药大学,山东济南250355

出　　处：《中国中医急症》2024年第4期571-576,共6页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82074227);山东省医药卫生科技发展计划项目(202117010252)。

摘　　要：目的通过Meta分析的方法了解慢性阻塞性肺疾病急性加重期(AECOPD)患者应用清金化痰汤联合西医常规治疗对其临床疗效的影响。方法通过检索中国知网(CNKI)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、万方数据库(WanFang)、PubMed、The Cochrane Library等数据库中关于清金化痰汤联合西医常规治疗对AECOPD患者临床疗效的随机对照研究,检索时间限定为建库以来至2023年8月31日。使用Review Manger5.3软件对所提取的数据进行Meta分析。结果共纳入25篇文献,纳入总数为2061例,其中观察组1037例,对照组1024例。观察组的临床疗效[MD=1.2,95%CI(1.15,1.25),P<0.00001]、PO2[MD=4.43,95%CI(3.52,5.35),P<0.01]、FEV1[MD=0.27,95%CI(0.17,0.37),P<0.01]、FEV1/FVC%[MD=4.4,95%CI(3.46,5.34),P<0.01]高于对照组,具有统计学差异;观察组的中医证候积分[MD=-3.2,95%CI(-4.06,-2.34),P<0.01]、PCO_(2)[MD=-5.93,95%CI(-7.11,-4.76),P<0.01]、WBC[MD=-0.7,95%CI(-1.05,-0.36),P<0.01]低于对照组,具有统计学差异。观察组CRP[MD=-2.11,95%CI(-4.57,0.36),P<0.09]相比于对照组虽有所降低,但差异无统计学意义。结论清金化痰汤联合西医常规治疗能更好地改善AECOPD患者的症状、肺功能及炎症指标。Objective:To investigate the effect of Qingjin Huatan Decoction combined with conventional western medicine on the clinical efficacy of acute exacerbations of chronic obstructive pulmonary disease(AECOPD)patients by meta-analysis.Methods:Databases of CNKI,VIP,CBM,Wanfang,PubMed and The Cochrane Library were searched from inception to August 31,2023 for randomized controlled studies on the clinical efficacy of Qingjin Huatan Decoction combined with conventional western medicine in patients with AECOPD.Meta analysis of the extracted data was performed using Review Manger 5.3 software.Results:A total of 2061 cases were included in 25 literatures,including 1037 cases in the observation group and 1024 cases in the control group.Clinical efficacy of the observation group[MD=1.2,95%CI(1.15,1.25),P<0.00001],PO2[MD=4.43,95%CI(3.52,5.35),P<0.01],FEV1[MD=0.27,95%CI(0.17,0.37),P<0.01],FEV1/FVC%[MD=4.4,95%CI(3.46,5.34),P<0.01]were higher than those in the control group,with statistical difference.The TCM syndrome scores of the observation group[MD=-3.2,95%CI(-4.06,-2.34),P<0.01],PCO_2[MD=-5.93,95%CI(-7.11,-4.76),P<0.01],WBC[MD=-0.7,95%CI(-1.05,-0.36),P<0.01]were lower than the control group,with statistical difference.CRP in the observation group[MD=-2.11,95%CI(-4.57,0.36),P<0.09]was lower than that in the control group,but there was no statistical difference.Conclusion:Qingjin Huatan Decoction combined with conventional western medicine can better improve the symptoms,pulmonary function and inflammatory indicators of patients with AECOPD.

关 键 词：慢性阻塞性肺疾病急性加重期 清金化痰汤 META分析 随机对照试验 

分 类 号：R563.9[医药卫生—呼吸系统]