宣肺通腑方干预急性肺损伤患者胃肠功能紊乱的临床观察  

Clinical Study on the Intervention of Xuanfei Tongfu Decoction on Gastrointestinal Dysfunction in Patients with Acute Lung Injury Based on the Theory of“Lung and Large Intestine Are in Harmony with Each Other”

作　　者：王亚坤[1] 余利美 陈雲 张美齐 俞振飞 Wang Yakun;Yu Limei;Chen Yun;Zhang Meiqi;Yu Zhenfei(Hangzhou TCM Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine,Zhejiang,Hangzhou 310044,China)

机构地区：[1]浙江中医药大学附属杭州市中医院,浙江杭州310044

出　　处：《中国中医急症》2024年第4期666-669,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2023ZL523);杭州市医药卫生科技计划(A20210223)。

摘　　要：目的观察基于“肺与大肠相表里”理论的宣肺通腑方干预急性肺损伤患者胃肠功能紊乱的疗效。方法将50例接受宣肺通腑汤联合乳果糖口服液治疗的急性肺损伤患者设为联合组,再收集同期同科室50例仅接受乳果糖口服液治疗的同类型患者设为对照组。比较两组临床症状积分,并根据病例信息整理患者胃肠激素、炎症指标变化,分析其安全性。结果治疗7 d后,两组临床症状积分均下降,且联合组低于对照组(P<0.05);两组血清胃动素、胃泌素、血管活性肠肽水平均上升(P<0.05),肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平均下降(P<0.05),且联合组变化幅度大于对照组(P<0.05);两组不良反应发生情况差异无统计学意义(P>0.05)。结论基于“肺与大肠相表里”理论宣肺通腑方干预急性肺损伤患者胃肠功能紊乱可能有较好的疗效,能够改善患者胃肠功能,减轻炎性反应,且安全性良好。Objective:To explore the curative effect of Xuanfei Tongfu Decoction on gastrointestinal dysfunction in patients with acute lung injury based on the theory of“lung and large intestine are in harmony with each other”.Methods:Fifty patients with acute lung injury treated with Xuanfei Tongfu Decoction combined with lactulose oral liquid in our hospital were collected as the combination group,and 50 patients of the same type treated with only lactulose oral liquid in the same department during the same period were collected as the control group.The clinical symptom scores of the two groups were compared,and the changes of gastrointestinal hormones and inflammation indexes were sorted out according to the case information,and their safety was analyzed.Results:After 7 days of treatment,the clinical symptom scores of both groups decreased,and the combined group was lower than the control group(P<0.05).Serum motilin,gastrin and vasoactive intestinal peptide levels were increased in both groups(P<0.05),while tumor necrosis factor,interleukin-6 and IL-1βlevels were decreased in both groups(P<0.05),and the changes in combination group were greater than those in control group(P<0.05).There was no statistical significance in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion:Based on the theory of“lung and large intestine are in harmony with each other”,Xuanfei Tongfu Decoction may have a better effect on gastrointestinal dysfunction in patients with acute lung injury,which can improve gastrointestinal function and reduce inflammatory response,and has good safety.

关 键 词：急性肺损伤 胃肠功能 宣肺通腑方 炎症指标 

分 类 号：R563[医药卫生—呼吸系统]