血浆抗凝血酶Ⅲ、D-二聚体、纤维蛋白原降解产物联合检测在突聋患者诊断和治疗中的临床分析  

Clinical Analysis of Combined Plasma Antithrombin Ⅲ,D-dimer,and Fibrinogen Degradation Product Assays in the Diagnosis and Treatment of Patients with Sudden Deafness

作　　者：谌祎玮 王宁 肖旭平[1] 周建波[1] Chen Yiwei;Wang Ning;Xiao Xuping(Department of Otolaryngology Head and Neck Surgery,Hunan Provincial People’s Hospital,Changsha,Hunan,410005,China)

机构地区：[1]湖南省人民医院耳鼻喉咽喉头颈外科,湖南长沙410005

出　　处：《黑龙江医学》2024年第7期781-783,共3页Heilongjiang Medical Journal

摘　　要：目的:通过对患者血浆抗凝血酶Ⅲ(AT-Ⅲ)、D-二聚体(D-dimer)、纤维蛋白原降解产物(FDP)的联合分析,探讨微血栓形成在不同类型突发感音神经性聋(SSNHL)中的临床价值。方法:选取2021年1月—2022年5月湖南省人民医院收治的60例突发性聋(SHL)患者作为突聋组,另选70例同期住院治疗的鼻中隔偏曲、声带息肉、耳前瘘管、成人鼾症中听力正常患者作为对照组,根据治疗前的纯音听阈结果将突聋组患者分为低频组12例、高频组18例、全频组30例,比较各组患者AT-Ⅲ、D-dimer、FDP水平。结果:突聋组D-dimer、FDP水平低于对照组,AT-Ⅲ高于对照组,差异有统计学意义(t=3.935、5.142、5.158,P<0.05);高频组、全频组D-dimer、FDP水平高于对照组、低频组,AT-Ⅲ水平低于对照组、低频组,差异有统计学意义(F=7.896、14.588、12.839,P<0.05)。结论:AT-Ⅲ、D-dimer、FDP联合检测方便快捷,准确度较高,可为临床上不同类型患者溶栓治疗提供理论依据,进而制定个体化诊疗方案,使用改善微循环、溶栓类药物,以获得更好的临床疗效。Objective:The clinical value of microthrombosis in different types of sudden sensorineural deafness(SSNHL)was investigated by the combined analysis of patients’plasma antithrombinⅢ(AT-Ⅲ),D-dimer(D-dimer),and fibrinogen degradation product(FDP).Methods:60 patients with sudden deafness admitted to the hospital from January 2021 to May 2022 were selected as the sudden deafness group,and another 70 patients with normal hearing in nasal septal deviation,vocal polyp,preauricular fistula,and adult snoring who were hospitalized in the same period were selected as the control group.According to the results of pure range,the patients of the sudden deafness group were divided into 12 patients in 100-frequency group,12 patients in high-frequency group,and 30 patients in full-frequency group.The levels of AT-Ⅲ,D-dimer and FDP were compared between the two groups.Results:The levels of D-dimer and FDP in the sudden deafness group were lower than those in the control group,and the levels of AT-Ⅲwere higher than those in the control group,and the differences were statistically significant(t=3.935,5.142,5.158;P<0.05).The levels of D-dimer and FDP in the high-frequency group and full-frequency group were higher than those in the control group and low-frequency group,and the levels of AT-Ⅲwere lower than those in the control group and low-frequency group,and the difference was statistically significant(F=7.896,14.588,12.839;P<0.05).Conclusion:The combined test of AT-Ⅲ,D-dimer and FDP is convenient and accurate,which provides a theoretical basis for thrombolytic therapy for different types of patients in the clinic,and then designates an individualized diagnosis and treatment plan for the use of microcirculation-improving and thrombolytic drugs in order to obtain better clinical efficacy.

关 键 词：突发感音神经性聋 抗凝血酶Ⅲ D-二聚体 纤维蛋白原降解产物 个体化治疗 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]