美满霉素与异维A酸对痤疮患者血清TNF-α、hs-CRP、IL-6水平、角质层含水量的影响分析  

Analysis of the Effects of Memantine and Isotretinoin on Serum TNF-alpha,Hs-CRP,IL-6 Levels,and Stratum Corneum Water Content in Patients with Acne Vulgaris

作　　者：李银针 贺亚杰 Li Yinzhen;He Yajie(Department of Dermatology,Yushi County People’s Hospital,Kaifeng,Henan,475500,China)

机构地区：[1]尉氏县人民医院皮肤科,河南开封475500 [2]河南大学第一附属医院皮肤科,河南开封475000

出　　处：《黑龙江医学》2024年第7期798-800,共3页Heilongjiang Medical Journal

基　　金：河南省医学科技攻关项目(LHGJ201802120)。

摘　　要：目的:探讨美满霉素与异维A酸对痤疮患者血清炎性因子及角质层含水量(MCOC)的影响。方法:选取2019年9月—2021年6月尉氏县人民医院收治的127例面部痤疮患者作为研究对象,根据治疗方案不同将患者分为对照组(n=63)与研究组(n=64)。对照组患者采用异维A酸治疗,研究组患者采用美满霉素联合异维A酸治疗,两组患者均治疗6周。对比两组患者治疗前后MCOC、肿瘤坏死因子α(TNF-α)、经表皮失水量(TEWL)、白细胞介素6(IL-6)、角质层样本蛋白质含量、C-反应蛋白(hs-CRP)水平及不良反应。结果:治疗后,研究组患者的TEWL、角质层样本蛋白质水平低于对照组,MCOC水平高于对照组,差异有统计学意义(t=3.703、2.769、3.504,P<0.05);治疗后,研究组患者的TNF-α、hs-CRP、IL-6水平均低于对照组,差异有统计学意义(t=4.280、19.008、3.512,P<0.05);两组患者不良反应比较,差异无统计学意义(χ^(2)=0.401,P>0.05)。结论:美满霉素联合异维A酸治疗能够有效提高痤疮患者角质层含水量,降低血清TNF-α、hs-CRP、IL-6水平并改善患者皮损症状。Objective:To investigate the effect of memantine and isotretinoin on serum inflammatory factors and stratum corneum water content in acne patients.Methods:127 cases of facial acne patients admitted to the hospital from September 2019 to June 2021 were selected as the study subjects,and the patients were divided into the control group(n=63)and the study group(n=64)according to the different treatment protocols.The control group was treated with isotretinoin and the study group was treated with memantine combined with isotretinoin,and both groups were treated for 6 weeks.The stratum corneum water content(MCOC),tumor necrosis factor alpha(TNF-α),transepidermal water loss(TEWL),interleukin 6(IL-6),protein content of stratum corneum samples,C-reactive protein(hs-CRP)levels,and adverse reactions were compared between the two groups before and after treatment.Results:After treatment,the study group had lower levels of TEWL and stratum corneum sample proteins and higher levels of MCOC than the control group,with statistically significant differences(t=3.703,2.769,3.504;P<0.05).After treatment,the levels of TNF-α,hs-CRP,and IL-6 in the study group were lower than those in the control group,and the difference was statistically significant(t=4.280,19.008,3.512,P<0.05).There was no statistically significant difference in the comparison of adverse reactions between the two groups(χ^(2)=0.401;P<0.05).Conclusion:Treatment with memantine in combination with isotretinoin was effective in increasing the water content of the stratum corneum,decreasing serum TNF-α,hs-CRP,and IL-6 levels,and improving the symptoms of skin lesions in patients with acne.

关 键 词：美满霉素 异维A酸 痤疮 角质层含水量 炎症因子 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]