多中心性网状组织细胞增生症1例并文献复习  

Multicentric Reticulohistiocytosis a Case Report and Literature Review

作　　者：张秀君[1] 郭涛[1] 顾安康[2] ZHANG Xiujun;GUO Tao;GU Ankang(Department of Dermatology,Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine,Tianjin 300120,China;Department of Pathology,Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine,Tianjin 300120,China)

机构地区：[1]天津市中医药研究院附属医院皮肤科,天津300120 [2]天津市中医药研究院附属医院病理科,天津300120

出　　处：《中国医药指南》2024年第12期186-188,共3页Guide of China Medicine

摘　　要：报告1例多中心性网状组织细胞增生症,并进行文献复习,旨在为今后的临床诊治提供指导。患者女,43岁,因双手甲皱、前胸及耳郭多发暗红色结节4年,双手关节炎病史5年,全身系统检查未见淋巴结肿大和内脏占位。辅助检查:双手X线片:远节指间关节面下骨质欠光整,关节面骨质硬化。组织病理检查:真皮内组织细胞数目增多,并见多核巨细胞,细胞膜清楚,内含均匀细颗粒状物质,呈“毛玻璃”状,PAS(+)。免疫组化:组织细胞CD68阳性,S-100和CD1a阴性。诊断:多中心性网状组织细胞增生症。A case of multicentric reticular histiocytosis is reported,along with a literature review aimed at providing guidance for future clinical diagnosis and treatment.A 43-year-old woman patient who presented with multiple dark red nodules in the nail folds of both hands,the anterior chest and the auricles for 4 years,a history of arthritis in both hands for 5 years,and no enlarged lymph nodes or visceral occupations on systemic examination.Ancillary examination:X-ray film of both hands:the bone under the articular surface of the distal interphalangeal joint was not smooth,and the articular surface was sclerotic.Histopathological examination:granulomatous proliferation of histiocytes was seen in the dermis,and multinucleated giant cells were seen,with clear cell membranes,obvious nuclei,rich cytoplasm and uniform fine granular material,which was in the form of"hairy glass".Immunohistochemistry:CD68(+),S-100(-),CD1a(-).Diagnosis:multicentric reticulohistiocytosis.

关 键 词：多中心性网状组织细胞增生症 诊断 治疗 

分 类 号：R751[医药卫生—皮肤病学与性病学] R597[医药卫生—临床医学]