不同精液质量不育症患者的外周血染色体核型分析  

Chromosomal karyotype analysis of peripheral blood in infertility patients with different semen quality

作　　者：孙惠霖 刘建兵 李敏 郑建丽 吴静 SUN Huilin;LIU Jianbing;LI Min;ZHENG Jianli;WU Jing(Medical Genetic Center,the Affiliated Yancheng Maternity&Child Health Hospital of Yangzhou University,Yancheng 224001,Jiangsu,China)

机构地区：[1]扬州大学附属盐城妇幼保健院(盐城市妇幼保健院)医学遗传中心,江苏盐城224001

出　　处：《中国现代医生》2024年第11期36-39,共4页China Modern Doctor

基　　金：江苏省盐城市医学科技发展计划项目(YK2021054)。

摘　　要：目的分析不同精液质量不育症患者外周血染色体核型异常的类型和发生率。方法选取2018年1月至2021年12月来笔者医院行外周血染色体G显带核型分析及精液分析的292例男性不育症患者,根据精液分析结果分为精液质量异常组和正常对照组,对检出的异常核型进行统计和分析。结果精液质量异常组检出异常染色体核型20例(18.87%),正常对照组检出异常染色体核型9例(4.84%),比较两组外周血染色体核型异常率差异具有统计学意义(P<0.05)。无精子症组患者染色体异常检出率为50%,性染色体异常为该组主要异常类型。结论对不育症患者行外周血染色体核型分析可有效分析病因,对辅助生殖、出生缺陷一级预防具有重要的临床意义。Objective To analyze the type and incidence of abnormal chromosome karyotype in peripheral blood of infertile patients with different semen quality.Methods Selectet 292 infertility patients who came to our hospital from January 2018 to December 2021 for G-banding karyotyping and semen analysis.According to the semen analysis results,the patients were divided into abnormal semen quality group and normal control group.We made statistics and analysis on the abnormal karyotypes.Results In the group with abnormal semen quality,20 cases(18.87%)of abnormal karyotypes were found.In the normal control group,9 cases(4.84%)had abnormal karyotypes were found.The comparison of the abnormal rates of peripheral blood chromosome karyotypes between the two groups showed statistical significance(P<0.05).The detection rate of chromosomal abnormalities in patients with Azoospermia was 50%,and sex chromosome abnormalities were the main types of abnormalities in this group.Conclusion Karyotype analysis of infertile patients can effectively analyze the causes of infertility,and has important clinical significance for assisted reproduction and primary prevention of birth defects.

关 键 词：不育症 精液质量 染色体核型分析 性染色体 

分 类 号：Q343.2[生物学—遗传学]